Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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hldEBifunctional protein HldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (480 aa)    
Predicted Functional Partners:
ALO41230.1
Phosphoheptose isomerase; Pfam:pfam13580 SIS domain.
  
 0.999
ALO41234.1
D,D-heptose 1,7-bisphosphate phosphatase; Pfam:pfam13242 HAD-hyrolase-like.
 
  
 0.988
ALO41233.1
Pfam:pfam01075 Glycosyltransferase family 9 (heptosyltransferase).
 
   
 0.870
ALO40845.1
DnaA initiator-associating protein DiaA; Pfam:pfam13580 SIS domain.
 
   
 0.822
ALO41229.1
Pfam:pfam14052 Capsule assembly protein Wzi.
       0.801
ALO41228.1
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
   
 0.681
lpxB
Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.584
hisB
Pfam:pfam00475 Imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family.
  
  
 0.574
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.561
lpxA
Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.515
Your Current Organism:
Pseudoalteromonas phenolica
NCBI taxonomy Id: 161398
Other names: IAM 14989, JCM 21460, KCTC 12086, P. phenolica, Pseudoalteromonas phenolica Isnansetyo and Kamei 2003, Pseudoalteromonas sp. O-BC30, strain O-BC30
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