node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ED21_19617 | ED21_19732 | ED21_19617 | ED21_19732 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | COG2214 DnaJ-class molecular chaperone. | 0.656 |
ED21_19617 | ED21_19987 | ED21_19617 | ED21_19987 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | 0.595 |
ED21_19617 | ED21_21384 | ED21_19617 | ED21_21384 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | COG2214 DnaJ-class molecular chaperone. | 0.595 |
ED21_19617 | ED21_24631 | ED21_19617 | ED21_24631 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | DnaJ-class molecular chaperone; COG0183 Acetyl-CoA acetyltransferase. | 0.595 |
ED21_19617 | ED21_25582 | ED21_19617 | ED21_25582 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein; COG0790 FOG: TPR repeat, SEL1 subfamily. | 0.561 |
ED21_19617 | dnaJ | ED21_19617 | ED21_27488 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | DnaJ molecular chaperone; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.669 |
ED21_19617 | dnaK | ED21_19617 | ED21_27483 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.989 |
ED21_19617 | groEL | ED21_19617 | ED21_20704 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.601 |
ED21_19617 | grpE | ED21_19617 | ED21_27453 | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.860 |
ED21_19732 | ED21_19617 | ED21_19732 | ED21_19617 | COG2214 DnaJ-class molecular chaperone. | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.656 |
ED21_19732 | ED21_25582 | ED21_19732 | ED21_25582 | COG2214 DnaJ-class molecular chaperone. | Hypothetical protein; COG0790 FOG: TPR repeat, SEL1 subfamily. | 0.934 |
ED21_19732 | clpB | ED21_19732 | ED21_31119 | COG2214 DnaJ-class molecular chaperone. | ATP-dependent Clp protease; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.656 |
ED21_19732 | dnaK | ED21_19732 | ED21_27483 | COG2214 DnaJ-class molecular chaperone. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
ED21_19732 | groEL | ED21_19732 | ED21_20704 | COG2214 DnaJ-class molecular chaperone. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.779 |
ED21_19732 | grpE | ED21_19732 | ED21_27453 | COG2214 DnaJ-class molecular chaperone. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.931 |
ED21_19987 | ED21_19617 | ED21_19987 | ED21_19617 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | ATPase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.595 |
ED21_19987 | ED21_25582 | ED21_19987 | ED21_25582 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Hypothetical protein; COG0790 FOG: TPR repeat, SEL1 subfamily. | 0.934 |
ED21_19987 | clpB | ED21_19987 | ED21_31119 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | ATP-dependent Clp protease; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.595 |
ED21_19987 | dnaK | ED21_19987 | ED21_27483 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.981 |
ED21_19987 | groEL | ED21_19987 | ED21_20704 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.620 |