STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRN74789.1Atp-dependent clp protease, atp-binding subunit clpa; Belongs to the ClpA/ClpB family. (626 aa)    
Predicted Functional Partners:
dnaK
Hypothetical protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.846
clpP
Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.826
KRN75107.1
Hypothetical protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.
    
 
 0.736
KRN74788.1
Hypothetical protein.
       0.727
KRN75827.1
Hypothetical protein.
  
 
 0.713
KRN74787.1
Hypothetical protein.
  
  
 0.690
KRN74786.1
Hypothetical protein.
       0.680
infB
infB protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
   
 
 0.555
grpE
Hypothetical protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dep [...]
  
 
 0.554
KRN74790.1
Conjugation protein.
       0.549
Your Current Organism:
Weissella kandleri
NCBI taxonomy Id: 1616
Other names: ATCC 51149, BCRC 14624, CCRC 14624, CCRC:14624, CCUG 32237, CIP 102809, DSM 20593, JCM 5817, LMG 18979, LMG:18979, Lactobacillus kandleri, NCFB 2753, NCIMB 702753, W. kandleri, strain L250
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.