phoR_3 protein (candidate division WS6 bacterium OLB20)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

phoR_3

Alkaline phosphatase synthesis sensor protein PhoR. (690 aa)

Predicted Functional Partners:

phoR_2

0.956

yycF

0.948

phoP

0.948

KXK26054.1

0.940

tcrA

0.938

arlR

0.919

pleC_1

0.913

KXK27267.1

0.896

kdpE

0.878

KXK26083.1

0.855

Your Current Organism:

candidate division WS6 bacterium OLB20

NCBI taxonomy Id: 1617426
Other names: c. division WS6 bacterium OLB20

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KXK26054.1	KXK26083.1	TR69_WS6001001348	TR69_WS6001001377	Bacterial extracellular solute-binding protein, family 3.	Hypothetical protein.	0.999
KXK26054.1	KXK27267.1	TR69_WS6001001348	TR69_WS6001000141	Bacterial extracellular solute-binding protein, family 3.	Sensory histidine kinase CreC.	0.999
KXK26054.1	arlR	TR69_WS6001001348	TR69_WS6001001303	Bacterial extracellular solute-binding protein, family 3.	Response regulator ArlR.	0.993
KXK26054.1	kdpE	TR69_WS6001001348	TR69_WS6001000558	Bacterial extracellular solute-binding protein, family 3.	KDP operon transcriptional regulatory protein KdpE.	0.993
KXK26054.1	phoP	TR69_WS6001001348	TR69_WS6001000632	Bacterial extracellular solute-binding protein, family 3.	Alkaline phosphatase synthesis transcriptional regulatory protein PhoP.	0.993
KXK26054.1	phoR_2	TR69_WS6001001348	TR69_WS6001000801	Bacterial extracellular solute-binding protein, family 3.	Alkaline phosphatase synthesis sensor protein PhoR.	0.999
KXK26054.1	phoR_3	TR69_WS6001001348	TR69_WS6001001123	Bacterial extracellular solute-binding protein, family 3.	Alkaline phosphatase synthesis sensor protein PhoR.	0.940
KXK26054.1	pleC_1	TR69_WS6001001348	TR69_WS6001000088	Bacterial extracellular solute-binding protein, family 3.	Non-motile and phage-resistance protein.	0.999
KXK26054.1	tcrA	TR69_WS6001001348	TR69_WS6001000936	Bacterial extracellular solute-binding protein, family 3.	Transcriptional regulatory protein TcrA.	0.994
KXK26054.1	yycF	TR69_WS6001001348	TR69_WS6001000197	Bacterial extracellular solute-binding protein, family 3.	Transcriptional regulatory protein YycF.	0.993
KXK26083.1	KXK26054.1	TR69_WS6001001377	TR69_WS6001001348	Hypothetical protein.	Bacterial extracellular solute-binding protein, family 3.	0.999
KXK26083.1	KXK27267.1	TR69_WS6001001377	TR69_WS6001000141	Hypothetical protein.	Sensory histidine kinase CreC.	0.999
KXK26083.1	arlR	TR69_WS6001001377	TR69_WS6001001303	Hypothetical protein.	Response regulator ArlR.	0.963
KXK26083.1	kdpE	TR69_WS6001001377	TR69_WS6001000558	Hypothetical protein.	KDP operon transcriptional regulatory protein KdpE.	0.963
KXK26083.1	phoP	TR69_WS6001001377	TR69_WS6001000632	Hypothetical protein.	Alkaline phosphatase synthesis transcriptional regulatory protein PhoP.	0.963
KXK26083.1	phoR_2	TR69_WS6001001377	TR69_WS6001000801	Hypothetical protein.	Alkaline phosphatase synthesis sensor protein PhoR.	0.999
KXK26083.1	phoR_3	TR69_WS6001001377	TR69_WS6001001123	Hypothetical protein.	Alkaline phosphatase synthesis sensor protein PhoR.	0.855
KXK26083.1	pleC_1	TR69_WS6001001377	TR69_WS6001000088	Hypothetical protein.	Non-motile and phage-resistance protein.	0.999
KXK26083.1	tcrA	TR69_WS6001001377	TR69_WS6001000936	Hypothetical protein.	Transcriptional regulatory protein TcrA.	0.963
KXK26083.1	yycF	TR69_WS6001001377	TR69_WS6001000197	Hypothetical protein.	Transcriptional regulatory protein YycF.	0.963

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.706

expected number of edges:

12

PPI enrichment p-value:

0.0413

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006220

Pyrimidine nucleotide metabolic process

4 of 21

2.0

2.1

5.06e-05

GO:0009218

Pyrimidine ribonucleotide metabolic process

3 of 12

2.12

1.84

0.00026

GO:0009123

Nucleoside monophosphate metabolic process

4 of 46

1.66

1.64

0.00019

GO:0009117

Nucleotide metabolic process

6 of 121

1.42

1.56

5.06e-05

GO:0009165

Nucleotide biosynthetic process

5 of 89

1.47

1.54

0.00011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019205

Nucleobase-containing compound kinase activity

4 of 9

2.37

2.83

3.49e-06

GO:0019206

Nucleoside kinase activity

2 of 3

2.55

1.17

0.0073

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

2 of 11

1.98

0.99

0.0128

GO:0035639

Purine ribonucleoside triphosphate binding

6 of 421

0.88

0.62

0.0073

GO:0032555

Purine ribonucleotide binding

6 of 422

0.88

0.62

0.0073

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 1717

0.49

0.37

0.0052

GO:0005737

Cytoplasm

9 of 1574

0.48

0.34

0.0156

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1451

Mixed, incl. Coenzyme A metabolic process, and Pantothenate biosynthesis

4 of 15

2.15

2.47

1.14e-05

CL:1289

Mixed, incl. Nucleoside monophosphate metabolic process, and Folate biosynthesis

7 of 96

1.59

2.39

1.79e-07

CL:1469

Chromosome segregation, and rRNA pseudouridine synthesis

3 of 6

2.42

2.05

0.00014

CL:1291

Ribonucleoside monophosphate metabolic process, and Pyrimidine metabolism

3 of 58

1.44

0.65

0.0444

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

6 of 68

1.67

2.54

2.00e-07

map00230

Purine metabolism

4 of 113

1.27

0.98

0.0030

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

6 of 482

0.82

0.47

0.0354

GOCC:0005737

Cytoplasm

8 of 1127

0.57

0.36

0.0354

GOCC:0005622

Intracellular

9 of 1664

0.46

0.3

0.0436

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0547

Nucleotide-binding

6 of 301

1.02

0.83

0.0016

KW-0963

Cytoplasm

5 of 224

1.07

0.81

0.0036

KW-0418

Kinase

4 of 171

1.09

0.68

0.0155

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