STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSAPEP00000001550Nei-like DNA glycosylase 3. (559 aa)    
Predicted Functional Partners:
NTHL1
Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.
  
  
 0.915
ENSAPEP00000020432
Dephospho-CoA kinase domain containing.
  
  
 0.910
ENSAPEP00000020527
CoA synthase.
  
  
 0.910
ENSAPEP00000028280
Ttk protein kinase.
   
    0.786
ENSAPEP00000000408
Uncharacterized protein.
   
    0.782
ENSAPEP00000000411
Discs, large (Drosophila) homolog-associated protein 5.
   
    0.782
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
  
 0.767
ENSAPEP00000019308
Zgc:110269.
  
  
 0.767
ENSAPEP00000006227
Polymerase (DNA directed) nu.
  
  
 0.762
ENSAPEP00000011988
Polymerase (DNA directed), gamma.
  
  
 0.762
Your Current Organism:
Amphiprion percula
NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish
Server load: high (88%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.