STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)    
Predicted Functional Partners:
KYNU
Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.
  
 
 0.994
ENSAPEP00000004852
Acetylserotonin O-methyltransferase-like.
    
 
 0.994
ENSAPEP00000020306
Arylformamidase.
  
 
 0.960
ENSAPEP00000021857
Indoleamine 2,3-dioxygenase 1.
   
 
 0.947
TPH1
Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a.
  
 
 0.929
ENSAPEP00000010443
Uncharacterized protein.
   
 
 0.904
ENSAPEP00000008623
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
  
 
 0.895
ENSAPEP00000013314
Coagulation factor VII; Belongs to the peptidase S1 family.
   
  
 0.882
ENSAPEP00000016814
Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase).
  
 
 0.860
KYAT3
Kynurenine aminotransferase 3.
  
 
 0.857
Your Current Organism:
Amphiprion percula
NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish
Server load: low (28%) [HD]