STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSAPEP00000004491Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)    
Predicted Functional Partners:
ENSAPEP00000001760
ARID domain-containing protein.
    
 0.983
ENSAPEP00000033803
Translocase of outer mitochondrial membrane 20.
    
 0.983
ENSAPEP00000034873
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 0.982
ENSAPEP00000012032
Nuclear receptor corepressor 2.
    
 0.971
ENSAPEP00000015576
SDS3 homolog, SIN3A corepressor complex component.
    
 0.951
ENSAPEP00000024521
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 0.940
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
   
 0.938
ENSAPEP00000029944
Recombination signal binding protein for immunoglobulin kappa J region a.
   
 0.938
ENSAPEP00000008461
Sap30-like.
    
 0.937
ENSAPEP00000022356
Nuclear receptor corepressor 1.
    
 0.937
Your Current Organism:
Amphiprion percula
NCBI taxonomy Id: 161767
Other names: A. percula, Picasso clownfish, orange clownfish
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