node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADSSL1 | ENSAPEP00000028492 | ENSAPEP00000000833 | ENSAPEP00000028492 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Guanine monophosphate synthase. | 0.590 |
ADSSL1 | ENSAPEP00000034509 | ENSAPEP00000000833 | ENSAPEP00000034509 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.990 |
ADSSL1 | GMPR | ENSAPEP00000000833 | ENSAPEP00000006965 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.967 |
ADSSL1 | GMPR-2 | ENSAPEP00000000833 | ENSAPEP00000015836 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.967 |
ADSSL1 | IMPDH | ENSAPEP00000000833 | ENSAPEP00000010183 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.967 |
ADSSL1 | ITPA | ENSAPEP00000000833 | ENSAPEP00000017685 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.962 |
ENSAPEP00000000214 | ENSAPEP00000028357 | ENSAPEP00000000214 | ENSAPEP00000028357 | GTP cyclohydrolase 1. | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | 0.874 |
ENSAPEP00000000214 | ENSAPEP00000031756 | ENSAPEP00000000214 | ENSAPEP00000031756 | GTP cyclohydrolase 1. | GTP cyclohydrolase 2. | 0.898 |
ENSAPEP00000000214 | ITPA | ENSAPEP00000000214 | ENSAPEP00000017685 | GTP cyclohydrolase 1. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.948 |
ENSAPEP00000028357 | ENSAPEP00000000214 | ENSAPEP00000028357 | ENSAPEP00000000214 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | GTP cyclohydrolase 1. | 0.874 |
ENSAPEP00000028357 | ENSAPEP00000031756 | ENSAPEP00000028357 | ENSAPEP00000031756 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | GTP cyclohydrolase 2. | 0.874 |
ENSAPEP00000028357 | ENSAPEP00000034980 | ENSAPEP00000028357 | ENSAPEP00000034980 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | Deoxyuridine triphosphatase. | 0.917 |
ENSAPEP00000028357 | ITPA | ENSAPEP00000028357 | ENSAPEP00000017685 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.949 |
ENSAPEP00000028492 | ADSSL1 | ENSAPEP00000028492 | ENSAPEP00000000833 | Guanine monophosphate synthase. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.590 |
ENSAPEP00000028492 | ENSAPEP00000034509 | ENSAPEP00000028492 | ENSAPEP00000034509 | Guanine monophosphate synthase. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.882 |
ENSAPEP00000028492 | ENSAPEP00000034980 | ENSAPEP00000028492 | ENSAPEP00000034980 | Guanine monophosphate synthase. | Deoxyuridine triphosphatase. | 0.400 |
ENSAPEP00000028492 | GMPR | ENSAPEP00000028492 | ENSAPEP00000006965 | Guanine monophosphate synthase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.990 |
ENSAPEP00000028492 | GMPR-2 | ENSAPEP00000028492 | ENSAPEP00000015836 | Guanine monophosphate synthase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.990 |
ENSAPEP00000028492 | IMPDH | ENSAPEP00000028492 | ENSAPEP00000010183 | Guanine monophosphate synthase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.993 |
ENSAPEP00000028492 | ITPA | ENSAPEP00000028492 | ENSAPEP00000017685 | Guanine monophosphate synthase. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.965 |