KRN28544.1 protein (Lactobacillus mali) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KRN28544.1

ErfK YbiS YcfS YnhG family protein. (456 aa)

Predicted Functional Partners:

KRN28540.1

0.546

KRN28541.1

0.526

KRN28542.1

0.526

KRN28543.1

0.526

KRN30410.1

0.513

KRN27038.1

0.502

KRN28538.1

0.474

KRN34347.1

0.458

KRN27104.1

0.456

KRN34386.1

0.455

Your Current Organism:

Lactobacillus mali

NCBI taxonomy Id: 1618
Other names: ATCC 27053, ATCC 27304 [[Lactobacillus yamanashiensis subsp. yamanashiensis]], CCUG 30141, CCUG 32228, CIP 103142, DSM 20444, KCTC 3596, L. mali, LMG 6899, LMG:6899, Lactobacillus yamanashiensis, Lactobacillus yamanashiensis subsp. mali, Lactobacillus yamanashiensis subsp. yamanashiensis, NBRC 102159, NCIB 10560, NCIB:10560, NCIMB 10560, NRRL B-4563

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRN27038.1	KRN27104.1	IV36_GL001233	IV36_GL001155	Hypothetical protein.	Hypothetical protein.	0.668
KRN27038.1	KRN28544.1	IV36_GL001233	IV36_GL000471	Hypothetical protein.	ErfK YbiS YcfS YnhG family protein.	0.502
KRN27038.1	KRN34347.1	IV36_GL001233	IV36_GL000147	Hypothetical protein.	Hypothetical protein.	0.454
KRN27104.1	KRN27038.1	IV36_GL001155	IV36_GL001233	Hypothetical protein.	Hypothetical protein.	0.668
KRN27104.1	KRN28544.1	IV36_GL001155	IV36_GL000471	Hypothetical protein.	ErfK YbiS YcfS YnhG family protein.	0.456
KRN28538.1	KRN28541.1	IV36_GL000465	IV36_GL000468	Hypothetical protein.	Hypothetical protein.	0.470
KRN28538.1	KRN28544.1	IV36_GL000465	IV36_GL000471	Hypothetical protein.	ErfK YbiS YcfS YnhG family protein.	0.474
KRN28540.1	KRN28541.1	IV36_GL000467	IV36_GL000468	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	Hypothetical protein.	0.791
KRN28540.1	KRN28542.1	IV36_GL000467	IV36_GL000469	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	Hypothetical protein.	0.773
KRN28540.1	KRN28543.1	IV36_GL000467	IV36_GL000470	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	Universal stress protein UspA family protein.	0.774
KRN28540.1	KRN28544.1	IV36_GL000467	IV36_GL000471	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	ErfK YbiS YcfS YnhG family protein.	0.546
KRN28541.1	KRN28538.1	IV36_GL000468	IV36_GL000465	Hypothetical protein.	Hypothetical protein.	0.470
KRN28541.1	KRN28540.1	IV36_GL000468	IV36_GL000467	Hypothetical protein.	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.791
KRN28541.1	KRN28542.1	IV36_GL000468	IV36_GL000469	Hypothetical protein.	Hypothetical protein.	0.866
KRN28541.1	KRN28543.1	IV36_GL000468	IV36_GL000470	Hypothetical protein.	Universal stress protein UspA family protein.	0.773
KRN28541.1	KRN28544.1	IV36_GL000468	IV36_GL000471	Hypothetical protein.	ErfK YbiS YcfS YnhG family protein.	0.526
KRN28542.1	KRN28540.1	IV36_GL000469	IV36_GL000467	Hypothetical protein.	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.773
KRN28542.1	KRN28541.1	IV36_GL000469	IV36_GL000468	Hypothetical protein.	Hypothetical protein.	0.866
KRN28542.1	KRN28543.1	IV36_GL000469	IV36_GL000470	Hypothetical protein.	Universal stress protein UspA family protein.	0.773
KRN28542.1	KRN28544.1	IV36_GL000469	IV36_GL000471	Hypothetical protein.	ErfK YbiS YcfS YnhG family protein.	0.526

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

27

PPI enrichment p-value:

8.74e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 116

1.57

3.2

1.96e-12

GO:0010467

Gene expression

11 of 211

1.35

2.4

1.96e-12

GO:0009059

Macromolecule biosynthetic process

11 of 268

1.25

2.03

6.02e-12

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 404

1.07

1.44

3.38e-10

GO:0044238

Primary metabolic process

11 of 1331

0.55

0.48

6.74e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 57

1.88

5.03

1.42e-15

GO:0019843

rRNA binding

6 of 41

1.8

2.88

8.24e-08

GO:0003676

Nucleic acid binding

7 of 522

0.76

0.54

0.0075

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.85

5.04

3.86e-16

GO:0044391

Ribosomal subunit

3 of 14

1.96

1.89

0.00014

GO:0015935

Small ribosomal subunit

2 of 6

2.15

1.39

0.0023

GO:0032991

Protein-containing complex

4 of 227

0.88

0.55

0.0189

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2421

rRNA-binding, and Structural constituent of ribosome

10 of 41

2.02

6.12

1.91e-17

CL:2419

Structural constituent of ribosome

11 of 58

1.91

5.73

2.92e-18

CL:2479

rRNA-binding, and RNA polymerase

6 of 12

2.33

4.99

4.39e-11

CL:2422

rRNA-binding, and Elongation factor G C-terminus

4 of 29

1.77

1.95

4.65e-05

CL:2481

Ribosomal protein S5 domain 2-type fold, subgroup, and Structural constituent of ribosome

2 of 6

2.15

1.08

0.0094

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 59

1.86

5.09

3.29e-16

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 47

1.91

4.87

4.06e-14

GOCC:0015935

Small ribosomal subunit

4 of 12

2.15

2.79

2.27e-06

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 10

1.93

1.03

0.0102

GOCC:0032991

Protein-containing complex

6 of 589

0.64

0.4

0.0296

GOCC:0005622

Intracellular

11 of 1652

0.46

0.39

0.00036

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 58

1.87

5.1

4.47e-16

KW-0699

rRNA-binding

6 of 38

1.83

3.17

1.46e-08

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