node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRN27312.1 | mscL | IV36_GL001039 | IV36_GL001526 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. | 0.616 |
KRN27312.1 | murD | IV36_GL001039 | IV36_GL000116 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.701 |
KRN27312.1 | murI | IV36_GL001039 | IV36_GL000831 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.704 |
KRN28285.1 | KRN30410.1 | IV36_GL000537 | IV36_GL002167 | NlpC P60. | N-acetylmuramoyl-L-alanine amidase. | 0.787 |
KRN28285.1 | KRN32067.1 | IV36_GL000537 | IV36_GL001318 | NlpC P60. | Glutamate synthase large subunit. | 0.433 |
KRN28285.1 | murI | IV36_GL000537 | IV36_GL000831 | NlpC P60. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.563 |
KRN30410.1 | KRN28285.1 | IV36_GL002167 | IV36_GL000537 | N-acetylmuramoyl-L-alanine amidase. | NlpC P60. | 0.787 |
KRN30410.1 | KRN31612.1 | IV36_GL002167 | IV36_GL001734 | N-acetylmuramoyl-L-alanine amidase. | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.743 |
KRN30410.1 | guaB | IV36_GL002167 | IV36_GL001849 | N-acetylmuramoyl-L-alanine amidase. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.897 |
KRN30410.1 | murI | IV36_GL002167 | IV36_GL000831 | N-acetylmuramoyl-L-alanine amidase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.701 |
KRN31185.1 | KRN32067.1 | IV36_GL001996 | IV36_GL001318 | L-asparaginase. | Glutamate synthase large subunit. | 0.941 |
KRN31185.1 | murI | IV36_GL001996 | IV36_GL000831 | L-asparaginase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.576 |
KRN31612.1 | KRN30410.1 | IV36_GL001734 | IV36_GL002167 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | N-acetylmuramoyl-L-alanine amidase. | 0.743 |
KRN31612.1 | KRN32067.1 | IV36_GL001734 | IV36_GL001318 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase large subunit. | 0.654 |
KRN31612.1 | guaB | IV36_GL001734 | IV36_GL001849 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.937 |
KRN31612.1 | murD | IV36_GL001734 | IV36_GL000116 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.495 |
KRN31612.1 | murI | IV36_GL001734 | IV36_GL000831 | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.953 |
KRN32067.1 | KRN28285.1 | IV36_GL001318 | IV36_GL000537 | Glutamate synthase large subunit. | NlpC P60. | 0.433 |
KRN32067.1 | KRN31185.1 | IV36_GL001318 | IV36_GL001996 | Glutamate synthase large subunit. | L-asparaginase. | 0.941 |
KRN32067.1 | KRN31612.1 | IV36_GL001318 | IV36_GL001734 | Glutamate synthase large subunit. | HAM1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.654 |