node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRN27315.1 | KRN30698.1 | IV36_GL001042 | IV36_GL002059 | CBS domain containing protein. | Adenine phosphoribosyltransferase. | 0.404 |
KRN27315.1 | apt | IV36_GL001042 | IV36_GL000061 | CBS domain containing protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.404 |
KRN27315.1 | guaA | IV36_GL001042 | IV36_GL001204 | CBS domain containing protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.992 |
KRN27315.1 | guaB | IV36_GL001042 | IV36_GL001849 | CBS domain containing protein. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.878 |
KRN27315.1 | xpt | IV36_GL001042 | IV36_GL001539 | CBS domain containing protein. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.404 |
KRN30698.1 | KRN27315.1 | IV36_GL002059 | IV36_GL001042 | Adenine phosphoribosyltransferase. | CBS domain containing protein. | 0.404 |
KRN30698.1 | guaA | IV36_GL002059 | IV36_GL001204 | Adenine phosphoribosyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.989 |
KRN30698.1 | guaB | IV36_GL002059 | IV36_GL001849 | Adenine phosphoribosyltransferase. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.914 |
KRN30698.1 | guaC | IV36_GL002059 | IV36_GL001641 | Adenine phosphoribosyltransferase. | Guanosine 5-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.910 |
KRN30698.1 | pyrG | IV36_GL002059 | IV36_GL001025 | Adenine phosphoribosyltransferase. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.492 |
KRN30698.1 | xpt | IV36_GL002059 | IV36_GL001539 | Adenine phosphoribosyltransferase. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.895 |
apt | KRN27315.1 | IV36_GL000061 | IV36_GL001042 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CBS domain containing protein. | 0.404 |
apt | guaA | IV36_GL000061 | IV36_GL001204 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.992 |
apt | guaB | IV36_GL000061 | IV36_GL001849 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.914 |
apt | guaC | IV36_GL000061 | IV36_GL001641 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine 5-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.945 |
apt | pyrG | IV36_GL000061 | IV36_GL001025 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.423 |
apt | xpt | IV36_GL000061 | IV36_GL001539 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.917 |
argS | guaA | IV36_GL001683 | IV36_GL001204 | arginyl-tRNA synthetase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.997 |
argS | guaB | IV36_GL001683 | IV36_GL001849 | arginyl-tRNA synthetase. | Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.435 |
argS | lysS | IV36_GL001683 | IV36_GL001054 | arginyl-tRNA synthetase. | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.915 |