STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KMK67572.1Type I restriction-modification system methyltransferase subunit; PFAM: N-6 DNA Methylase; HsdM N-terminal domain. (512 aa)    
Predicted Functional Partners:
KMK67573.1
PFAM: Type I restriction modification DNA specificity domain.
 
 0.996
KMK64162.1
Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
 
 0.979
KMK64159.1
PFAM: Type I restriction modification DNA specificity domain.
 
 
 0.972
KMK67576.1
Helicase, type I site-specific restriction-modification system restriction subunit; PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Helicase conserved C-terminal domain; EcoEI R protein C-terminal; Type III restriction enzyme, res subunit; Domain of unknown function (DUF4145).
 
 
 0.969
KMK64156.1
Hypothetical protein.
  
 
 0.928
KMK67574.1
Hypothetical protein.
       0.781
KMK64158.1
PFAM: Virulence protein RhuM family.
 
    0.703
KMK66458.1
PFAM: Mrr N-terminal domain; Restriction endonuclease.
 
  
 0.664
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
 
 0.567
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.460
Your Current Organism:
Puniceibacterium sp. IMCC21224
NCBI taxonomy Id: 1618204
Other names: P. sp. IMCC21224
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.