STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AJT42630.1DNA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (297 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 
0.927
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.868
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.640
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.599
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.582
AJT42631.1
FAD-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.576
AJT41319.1
Exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.512
AJT43117.1
DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.496
AJT41948.1
3'-5' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.464
AJT42632.1
MFS transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.438
Your Current Organism:
Psychromicrobium lacuslunae
NCBI taxonomy Id: 1618207
Other names: Arthrobacter sp. IHBB 11108, JCM 31143, KACC 19070, MCC 2780, MTCC 12460, P. lacuslunae, strain IHBB 11108
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