KKQ95174.1 protein (candidate division CPR2 bacterium GW2011GWC23910)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KKQ95174.1

Type II secretion system protein E. (597 aa)

Predicted Functional Partners:

KKQ95171.1

0.940

KKQ94954.1

0.911

KKQ94939.1

0.910

KKQ95177.1

0.874

KKQ95178.1

0.865

KKQ95172.1

0.849

KKQ95175.1

0.752

KKQ95176.1

0.752

KKQ95156.1

0.639

KKQ95173.1

0.598

Your Current Organism:

candidate division CPR2 bacterium GW2011GWC23910

NCBI taxonomy Id: 1618345
Other names: c. division CPR2 bacterium GW2011_GWC2_39_10, candidate division CPR2 bacterium GW2011_GWC2_39_10

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ94939.1	KKQ95156.1	UT18_C0006G0037	UT18_C0003G0015	PulF protein.	Two-component hybrid sensor and regulator.	0.483
KKQ94939.1	KKQ95172.1	UT18_C0006G0037	UT18_C0003G0031	PulF protein.	Twitching motility protein.	0.645
KKQ94939.1	KKQ95174.1	UT18_C0006G0037	UT18_C0003G0033	PulF protein.	Type II secretion system protein E.	0.910
KKQ94939.1	KKQ95177.1	UT18_C0006G0037	UT18_C0003G0036	PulF protein.	Hypothetical protein.	0.511
KKQ94939.1	KKQ95178.1	UT18_C0006G0037	UT18_C0003G0037	PulF protein.	Type IV pilus assembly protein PilM.	0.567
KKQ94954.1	KKQ95156.1	UT18_C0006G0052	UT18_C0003G0015	Type II secretion system protein F.	Two-component hybrid sensor and regulator.	0.483
KKQ94954.1	KKQ95172.1	UT18_C0006G0052	UT18_C0003G0031	Type II secretion system protein F.	Twitching motility protein.	0.634
KKQ94954.1	KKQ95174.1	UT18_C0006G0052	UT18_C0003G0033	Type II secretion system protein F.	Type II secretion system protein E.	0.911
KKQ94954.1	KKQ95177.1	UT18_C0006G0052	UT18_C0003G0036	Type II secretion system protein F.	Hypothetical protein.	0.511
KKQ94954.1	KKQ95178.1	UT18_C0006G0052	UT18_C0003G0037	Type II secretion system protein F.	Type IV pilus assembly protein PilM.	0.550
KKQ95156.1	KKQ94939.1	UT18_C0003G0015	UT18_C0006G0037	Two-component hybrid sensor and regulator.	PulF protein.	0.483
KKQ95156.1	KKQ94954.1	UT18_C0003G0015	UT18_C0006G0052	Two-component hybrid sensor and regulator.	Type II secretion system protein F.	0.483
KKQ95156.1	KKQ95171.1	UT18_C0003G0015	UT18_C0003G0030	Two-component hybrid sensor and regulator.	Type II secretion system protein.	0.483
KKQ95156.1	KKQ95172.1	UT18_C0003G0015	UT18_C0003G0031	Two-component hybrid sensor and regulator.	Twitching motility protein.	0.582
KKQ95156.1	KKQ95174.1	UT18_C0003G0015	UT18_C0003G0033	Two-component hybrid sensor and regulator.	Type II secretion system protein E.	0.639
KKQ95156.1	KKQ95177.1	UT18_C0003G0015	UT18_C0003G0036	Two-component hybrid sensor and regulator.	Hypothetical protein.	0.439
KKQ95171.1	KKQ95156.1	UT18_C0003G0030	UT18_C0003G0015	Type II secretion system protein.	Two-component hybrid sensor and regulator.	0.483
KKQ95171.1	KKQ95172.1	UT18_C0003G0030	UT18_C0003G0031	Type II secretion system protein.	Twitching motility protein.	0.918
KKQ95171.1	KKQ95173.1	UT18_C0003G0030	UT18_C0003G0032	Type II secretion system protein.	S23 ribosomal protein.	0.672
KKQ95171.1	KKQ95174.1	UT18_C0003G0030	UT18_C0003G0033	Type II secretion system protein.	Type II secretion system protein E.	0.940

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.868

expected number of edges:

12

PPI enrichment p-value:

0.000125

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

7 of 22

2.47

5.95

7.82e-13

GO:0018343

Protein farnesylation

2 of 2

2.96

1.5

0.0019

GO:0019408

Dolichol biosynthetic process

2 of 4

2.66

1.31

0.0041

GO:1901615

Organic hydroxy compound metabolic process

4 of 105

1.54

1.27

0.0013

GO:0016114

Terpenoid biosynthetic process

2 of 11

2.22

1.02

0.0130

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

8 of 41

2.25

6.02

3.64e-14

GO:0004659

Prenyltransferase activity

6 of 12

2.66

5.89

3.86e-12

GO:0004660

Protein farnesyltransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004337

Geranyltranstransferase activity

2 of 2

2.96

1.47

0.0022

GO:0004161

Dimethylallyltranstransferase activity

2 of 2

2.96

1.47

0.0022

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.27

0.0051

GO:1990234

Transferase complex

5 of 345

1.12

0.78

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9992

Isoprenoid biosynthetic process, and Protein farnesylation

9 of 18

2.66

9.3

1.21e-19

CL:9995

Prenyltransferase activity

6 of 6

2.96

6.98

8.26e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

8 of 30

2.39

7.12

4.13e-16

map01110

Biosynthesis of secondary metabolites

8 of 447

1.22

1.61

1.61e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 7

2.6

2.14

0.00011

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 22

2.1

1.55

0.0010

MAP-191273

Cholesterol biosynthesis

3 of 24

2.06

1.54

0.0010

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

3 of 39

1.85

1.3

0.0025

MAP-2142789

Ubiquinol biosynthesis

2 of 8

2.36

1.15

0.0074

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

2.96

1.21

0.0064

GOCC:0005965

Protein farnesyltransferase complex

2 of 2

2.96

1.21

0.0064

GOCC:1990234

Transferase complex

5 of 374

1.09

0.74

0.0091

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0808

Transferase

5 of 336

1.14

0.86

0.0037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00348

Polyprenyl synthetase

3 of 3

2.96

2.61

1.78e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033749

Polyprenyl synthetase, conserved site

3 of 3

2.96

2.36

5.09e-05

IPR000092

Polyprenyl synthetase

3 of 3

2.96

2.36

5.09e-05

IPR008949

Isoprenoid synthase domain superfamily

3 of 5

2.74

2.34

5.09e-05

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

2.96

1.31

0.0043

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