STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (203 aa)    
Predicted Functional Partners:
KKQ93717.1
Negative regulator of genetic competence clpC/mecB; Belongs to the ClpA/ClpB family.
  
 
 0.991
KKQ93632.1
Clp protease ATP binding subunit; Belongs to the ClpA/ClpB family.
  
 
 0.991
KKQ93731.1
Cysteine desulfurase.
  
  0.862
tig
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
 
  
 0.859
hrcA
Transcriptional regulator of heat shock protein; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.834
KKQ93938.1
TldD/PmbA family protein.
       0.773
KKQ93939.1
Peptidase U62 modulator of DNA gyrase.
       0.773
KKQ95156.1
Two-component hybrid sensor and regulator.
  
 
 0.751
KKQ94298.1
Aminotransferase, I and II.
   
  0.706
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.688
Your Current Organism:
candidate division CPR2 bacterium GW2011GWC23910
NCBI taxonomy Id: 1618345
Other names: c. division CPR2 bacterium GW2011_GWC2_39_10, candidate division CPR2 bacterium GW2011_GWC2_39_10
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.