node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KKP69484.1 | KKP69917.1 | UR67_C0006G0051 | UR67_C0002G0037 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 3-oxoacyl-(Acyl-carrier-protein) reductase. | 0.804 |
KKP69484.1 | KKP70185.1 | UR67_C0006G0051 | UR67_C0001G0094 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.797 |
KKP69484.1 | folD | UR67_C0006G0051 | UR67_C0001G0090 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.821 |
KKP69484.1 | glyA | UR67_C0006G0051 | UR67_C0001G0092 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.832 |
KKP69484.1 | thyA | UR67_C0006G0051 | UR67_C0006G0053 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
KKP69579.1 | KKP70185.1 | UR67_C0005G0068 | UR67_C0001G0094 | Aminotransferase, class IV. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.796 |
KKP69579.1 | glyA | UR67_C0005G0068 | UR67_C0001G0092 | Aminotransferase, class IV. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.436 |
KKP69579.1 | mltG | UR67_C0005G0068 | UR67_C0008G0039 | Aminotransferase, class IV. | YceG family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. | 0.765 |
KKP69579.1 | thyA | UR67_C0005G0068 | UR67_C0006G0053 | Aminotransferase, class IV. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.549 |
KKP69795.1 | KKP69937.1 | UR67_C0003G0073 | UR67_C0002G0057 | Capsular exopolysaccharide family. | Hypothetical protein. | 0.586 |
KKP69795.1 | KKP70185.1 | UR67_C0003G0073 | UR67_C0001G0094 | Capsular exopolysaccharide family. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.714 |
KKP69795.1 | folD | UR67_C0003G0073 | UR67_C0001G0090 | Capsular exopolysaccharide family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.712 |
KKP69917.1 | KKP69484.1 | UR67_C0002G0037 | UR67_C0006G0051 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.804 |
KKP69917.1 | KKP69937.1 | UR67_C0002G0037 | UR67_C0002G0057 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | Hypothetical protein. | 0.768 |
KKP69917.1 | KKP70185.1 | UR67_C0002G0037 | UR67_C0001G0094 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.730 |
KKP69917.1 | folD | UR67_C0002G0037 | UR67_C0001G0090 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.427 |
KKP69917.1 | glyA | UR67_C0002G0037 | UR67_C0001G0092 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.831 |
KKP69917.1 | thyA | UR67_C0002G0037 | UR67_C0006G0053 | 3-oxoacyl-(Acyl-carrier-protein) reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.790 |
KKP69937.1 | KKP69795.1 | UR67_C0002G0057 | UR67_C0003G0073 | Hypothetical protein. | Capsular exopolysaccharide family. | 0.586 |
KKP69937.1 | KKP69917.1 | UR67_C0002G0057 | UR67_C0002G0037 | Hypothetical protein. | 3-oxoacyl-(Acyl-carrier-protein) reductase. | 0.768 |