KKQ70798.1 protein (Shapirobacteria bacterium GW2011GWE23830)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

KKQ70798.1

Fe-S protein, radical SAM family. (495 aa)

Predicted Functional Partners:

KKQ71369.1

0.851

KKQ70799.1

0.840

KKQ69566.1

0.769

KKQ70796.1

0.736

KKQ69183.1

0.724

KKQ70797.1

0.722

KKQ71361.1

0.608

KKQ71375.1

0.608

KKQ71377.1

0.608

KKQ70791.1

0.608

Your Current Organism:

Shapirobacteria bacterium GW2011GWE23830

NCBI taxonomy Id: 1618490
Other names: C. Shapirobacteria bacterium GW2011_GWE2_38_30, Candidatus Shapirobacteria bacterium GW2011_GWE2_38_30

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ69183.1	KKQ69566.1	US90_C0018G0027	US90_C0015G0009	AstB/chuR-related protein.	UbiA prenyltransferase.	0.746
KKQ69183.1	KKQ70798.1	US90_C0018G0027	US90_C0005G0012	AstB/chuR-related protein.	Fe-S protein, radical SAM family.	0.724
KKQ69183.1	KKQ70799.1	US90_C0018G0027	US90_C0005G0013	AstB/chuR-related protein.	Fe-S oxidoreductase.	0.649
KKQ69183.1	KKQ71369.1	US90_C0018G0027	US90_C0003G0012	AstB/chuR-related protein.	Methyltransferase type 11.	0.539
KKQ69566.1	KKQ69183.1	US90_C0015G0009	US90_C0018G0027	UbiA prenyltransferase.	AstB/chuR-related protein.	0.746
KKQ69566.1	KKQ70791.1	US90_C0015G0009	US90_C0005G0005	UbiA prenyltransferase.	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	0.604
KKQ69566.1	KKQ70797.1	US90_C0015G0009	US90_C0005G0011	UbiA prenyltransferase.	Glycosyl transferase.	0.516
KKQ69566.1	KKQ70798.1	US90_C0015G0009	US90_C0005G0012	UbiA prenyltransferase.	Fe-S protein, radical SAM family.	0.769
KKQ69566.1	KKQ70799.1	US90_C0015G0009	US90_C0005G0013	UbiA prenyltransferase.	Fe-S oxidoreductase.	0.769
KKQ69566.1	KKQ71361.1	US90_C0015G0009	US90_C0003G0004	UbiA prenyltransferase.	Hypothetical protein.	0.604
KKQ69566.1	KKQ71369.1	US90_C0015G0009	US90_C0003G0012	UbiA prenyltransferase.	Methyltransferase type 11.	0.938
KKQ69566.1	KKQ71375.1	US90_C0015G0009	US90_C0003G0018	UbiA prenyltransferase.	Methyltransferase type 11.	0.604
KKQ69566.1	KKQ71377.1	US90_C0015G0009	US90_C0003G0020	UbiA prenyltransferase.	Methyltransferase type 11.	0.604
KKQ70791.1	KKQ69566.1	US90_C0005G0005	US90_C0015G0009	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	UbiA prenyltransferase.	0.604
KKQ70791.1	KKQ70798.1	US90_C0005G0005	US90_C0005G0012	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	Fe-S protein, radical SAM family.	0.608
KKQ70791.1	KKQ70799.1	US90_C0005G0005	US90_C0005G0013	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	Fe-S oxidoreductase.	0.608
KKQ70791.1	KKQ71369.1	US90_C0005G0005	US90_C0003G0012	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	Methyltransferase type 11.	0.883
KKQ70791.1	KKQ71375.1	US90_C0005G0005	US90_C0003G0018	Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase.	Methyltransferase type 11.	0.774
KKQ70796.1	KKQ70797.1	US90_C0005G0010	US90_C0005G0011	Hypothetical protein.	Glycosyl transferase.	0.764
KKQ70796.1	KKQ70798.1	US90_C0005G0010	US90_C0005G0012	Hypothetical protein.	Fe-S protein, radical SAM family.	0.736

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

0.0208

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 388

0.97

1.14

3.22e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

10 of 20

2.21

7.28

2.19e-18

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 636

0.75

7.24e-07

GO:0016021

Integral component of membrane

11 of 683

0.72

0.71

7.24e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4332

Quorum sensing, and Oligopeptide/dipeptide transporter, C-terminal region

11 of 59

1.78

4.84

5.43e-17

CL:4333

Quorum sensing

10 of 50

1.81

4.71

2.24e-15

CL:4334

Quorum sensing

9 of 41

1.86

4.57

7.96e-14

CL:4335

Quorum sensing

6 of 30

1.81

3.01

3.94e-08

CL:4336

Nickel cation transmembrane transporter activity, and Peptide transport

5 of 25

1.81

2.52

1.48e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fpla02024

Quorum sensing

10 of 66

1.69

4.05

1.05e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

11 of 70

1.71

4.58

5.92e-18

MAP-9635486

Infection with Mycobacterium tuberculosis

11 of 90

1.6

3.9

3.88e-17

MAP-5663205

Infectious disease

11 of 97

1.57

3.72

5.61e-17

MAP-1643685

Disease

11 of 97

1.57

3.72

5.61e-17

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

9 of 104

1.45

2.53

2.67e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

7 of 142

1.21

1.38

9.77e-06

KW-1003

Cell membrane

7 of 154

1.17

1.33

9.77e-06

KW-1133

Transmembrane helix

8 of 594

0.64

0.48

0.0038

KW-0812

Transmembrane

8 of 594

0.64

0.48

0.0038

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

10 of 43

1.88

5.07

1.12e-15

PF12911

N-terminal TM domain of oligopeptide transport permease C

5 of 6

2.43

4.05

1.11e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035906

MetI-like superfamily

7 of 37

1.79

3.14

9.63e-09

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

7 of 38

1.78

3.11

9.63e-09

IPR025966

Oligopeptide transport permease C-like, N-terminal domain

3 of 4

2.39

1.88

0.00030

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