STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (201 aa)    
Predicted Functional Partners:
KKW37757.1
ATP-dependent chaperone ClpB; Belongs to the ClpA/ClpB family.
  
 
 0.990
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.804
KKW37755.1
Cysteine desulfurase.
  
  0.749
KKW37348.1
Cysteine desulfurase.
  
  0.749
KKW37579.1
Trigger factor.
  
  
 0.721
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.707
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.690
rny
Ribonuclease Y; Endoribonuclease that initiates mRNA decay.
       0.682
KKW37576.1
Histone family protein DNA-binding protein; Belongs to the bacterial histone-like protein family.
  
  
 0.678
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
  
 
 0.600
Your Current Organism:
Adlerbacteria bacterium GW2011GWB1547
NCBI taxonomy Id: 1618607
Other names: C. Adlerbacteria bacterium GW2011_GWB1_54_7, Candidatus Adlerbacteria bacterium GW2011_GWB1_54_7, Parcubacteria (Adlerbacteria) bacterium GW2011_GWB1_54_7
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