AKM84142.1 protein (Campbellbacteria bacterium GW2011OD13428)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:

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Coexpression

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[Homology]

Score

AKM84142.1

RND family efflux transporter MFP subunit. (514 aa)

Predicted Functional Partners:

AKM83767.1

0.999

AKM84143.1

0.999

AKM84144.1

0.999

AKM83809.1

0.986

AKM84165.1

0.986

AKM83766.1

0.985

AKM84297.1

0.948

AKM84330.1

0.947

AKM83824.1

0.929

AKM83779.1

0.899

Your Current Organism:

Campbellbacteria bacterium GW2011OD13428

NCBI taxonomy Id: 1618633
Other names: C. Campbellbacteria bacterium GW2011_OD1_34_28, Candidatus Campbellbacteria bacterium GW2011_OD1_34_28, Parcubacteria (Campbellbacteria) bacterium GW2011_OD1_34_28

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKM83766.1	AKM83767.1	UR58_C0001G0049	UR58_C0001G0050	Hypothetical protein.	Antimicrobial peptide ABC transporter ATPase, putative ABC transport system ATP-binding protein.	0.999
AKM83766.1	AKM84142.1	UR58_C0001G0049	UR58_C0001G0425	Hypothetical protein.	RND family efflux transporter MFP subunit.	0.985
AKM83766.1	AKM84143.1	UR58_C0001G0049	UR58_C0001G0426	Hypothetical protein.	ABC transporter ATP-binding protein, putative ABC transport system ATP-binding protein.	0.999
AKM83766.1	AKM84144.1	UR58_C0001G0049	UR58_C0001G0427	Hypothetical protein.	Hypothetical protein.	0.953
AKM83767.1	AKM83766.1	UR58_C0001G0050	UR58_C0001G0049	Antimicrobial peptide ABC transporter ATPase, putative ABC transport system ATP-binding protein.	Hypothetical protein.	0.999
AKM83767.1	AKM84142.1	UR58_C0001G0050	UR58_C0001G0425	Antimicrobial peptide ABC transporter ATPase, putative ABC transport system ATP-binding protein.	RND family efflux transporter MFP subunit.	0.999
AKM83767.1	AKM84144.1	UR58_C0001G0050	UR58_C0001G0427	Antimicrobial peptide ABC transporter ATPase, putative ABC transport system ATP-binding protein.	Hypothetical protein.	0.998
AKM83779.1	AKM83809.1	UR58_C0001G0062	UR58_C0001G0092	TPR domain-containing protein.	Hypothetical protein.	0.637
AKM83779.1	AKM83824.1	UR58_C0001G0062	UR58_C0001G0107	TPR domain-containing protein.	Two component transcriptional regulator, two-component system, OmpR family, response regulator.	0.713
AKM83779.1	AKM84142.1	UR58_C0001G0062	UR58_C0001G0425	TPR domain-containing protein.	RND family efflux transporter MFP subunit.	0.899
AKM83779.1	AKM84165.1	UR58_C0001G0062	UR58_C0001G0448	TPR domain-containing protein.	Major facilitator superfamily transporter.	0.637
AKM83779.1	AKM84297.1	UR58_C0001G0062	UR58_C0001G0580	TPR domain-containing protein.	PAS/PAC sensor signal transduction histidine kinase.	0.793
AKM83779.1	AKM84330.1	UR58_C0001G0062	UR58_C0001G0613	TPR domain-containing protein.	Protein of unknown function with transmembrane region.	0.580
AKM83809.1	AKM83779.1	UR58_C0001G0092	UR58_C0001G0062	Hypothetical protein.	TPR domain-containing protein.	0.637
AKM83809.1	AKM84142.1	UR58_C0001G0092	UR58_C0001G0425	Hypothetical protein.	RND family efflux transporter MFP subunit.	0.986
AKM83824.1	AKM83779.1	UR58_C0001G0107	UR58_C0001G0062	Two component transcriptional regulator, two-component system, OmpR family, response regulator.	TPR domain-containing protein.	0.713
AKM83824.1	AKM84142.1	UR58_C0001G0107	UR58_C0001G0425	Two component transcriptional regulator, two-component system, OmpR family, response regulator.	RND family efflux transporter MFP subunit.	0.929
AKM83824.1	AKM84297.1	UR58_C0001G0107	UR58_C0001G0580	Two component transcriptional regulator, two-component system, OmpR family, response regulator.	PAS/PAC sensor signal transduction histidine kinase.	0.999
AKM84142.1	AKM83766.1	UR58_C0001G0425	UR58_C0001G0049	RND family efflux transporter MFP subunit.	Hypothetical protein.	0.985
AKM84142.1	AKM83767.1	UR58_C0001G0425	UR58_C0001G0050	RND family efflux transporter MFP subunit.	Antimicrobial peptide ABC transporter ATPase, putative ABC transport system ATP-binding protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.873

expected number of edges:

14

PPI enrichment p-value:

5.96e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

8 of 264

0.86

0.75

0.00037

GO:0006810

Transport

10 of 393

0.78

0.72

6.12e-05

GO:0071702

Organic substance transport

5 of 137

0.94

0.54

0.0303

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042626

ATPase-coupled transmembrane transporter activity

4 of 31

1.49

1.05

0.0043

GO:0140359

ABC-type transporter activity

3 of 18

1.6

0.92

0.0124

GO:0022857

Transmembrane transporter activity

6 of 253

0.75

0.47

0.0231

GO:0005524

ATP binding

6 of 281

0.71

0.43

0.0307

GO:0036094

Small molecule binding

7 of 442

0.58

0.36

0.0345

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

10 of 835

0.46

0.34

0.0108

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3497

Mixed, incl. Sulfur compound transport, and Periplasmic binding protein

4 of 7

2.13

2.62

5.21e-06

CL:3423

Mixed, incl. Binding-protein-dependent transport system inner membrane component, and Anion transport

6 of 44

1.51

1.98

2.93e-06

CL:3420

ABC transporters

7 of 86

1.29

1.6

2.93e-06

CL:3418

ABC transporters, and Tetrapyrrole metabolic process

8 of 120

1.2

1.46

2.14e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

9 of 145

1.17

1.57

3.28e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071944

Cell periphery

7 of 358

0.67

0.4

0.0384

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

5 of 137

0.94

0.54

0.0306

KW-1003

Cell membrane

5 of 140

0.93

0.53

0.0306

KW-0067

ATP-binding

6 of 246

0.76

0.46

0.0306

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

3 of 15

1.68

0.88

0.0174

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

6 of 98

1.16

0.00012

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