KKQ73471.1 protein (Falkowbacteria bacterium GW2011GWD23842)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KKQ73471.1

Hypothetical protein. (248 aa)

Predicted Functional Partners:

KKQ72517.1

0.856

KKQ73472.1

0.762

KKQ73473.1

0.746

KKQ73443.1

0.683

KKQ73449.1

0.683

KKQ73552.1

0.683

KKQ73370.1

0.683

KKQ72539.1

0.683

KKQ72284.1

0.670

KKQ73252.1

0.663

Your Current Organism:

Falkowbacteria bacterium GW2011GWD23842

NCBI taxonomy Id: 1618637
Other names: C. Falkowbacteria bacterium GW2011_GWD2_38_42, Candidatus Falkowbacteria bacterium GW2011_GWD2_38_42, Parcubacteria (Falkowbacteria) bacterium GW2011_GWD2_38_42

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ72284.1	KKQ72517.1	US93_C0011G0008	US93_C0008G0073	Hypothetical protein.	Hypothetical protein.	0.900
KKQ72284.1	KKQ72539.1	US93_C0011G0008	US93_C0008G0095	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72284.1	KKQ73252.1	US93_C0011G0008	US93_C0002G0053	Hypothetical protein.	Hypothetical protein.	0.512
KKQ72284.1	KKQ73370.1	US93_C0011G0008	US93_C0002G0171	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72284.1	KKQ73443.1	US93_C0011G0008	US93_C0001G0013	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72284.1	KKQ73449.1	US93_C0011G0008	US93_C0001G0019	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72284.1	KKQ73471.1	US93_C0011G0008	US93_C0001G0041	Hypothetical protein.	Hypothetical protein.	0.670
KKQ72284.1	KKQ73472.1	US93_C0011G0008	US93_C0001G0042	Hypothetical protein.	Hypothetical protein.	0.670
KKQ72284.1	KKQ73552.1	US93_C0011G0008	US93_C0001G0122	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72517.1	KKQ72284.1	US93_C0008G0073	US93_C0011G0008	Hypothetical protein.	Hypothetical protein.	0.900
KKQ72517.1	KKQ72539.1	US93_C0008G0073	US93_C0008G0095	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72517.1	KKQ73370.1	US93_C0008G0073	US93_C0002G0171	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72517.1	KKQ73443.1	US93_C0008G0073	US93_C0001G0013	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72517.1	KKQ73449.1	US93_C0008G0073	US93_C0001G0019	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72517.1	KKQ73471.1	US93_C0008G0073	US93_C0001G0041	Hypothetical protein.	Hypothetical protein.	0.856
KKQ72517.1	KKQ73472.1	US93_C0008G0073	US93_C0001G0042	Hypothetical protein.	Hypothetical protein.	0.856
KKQ72517.1	KKQ73552.1	US93_C0008G0073	US93_C0001G0122	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72539.1	KKQ72284.1	US93_C0008G0095	US93_C0011G0008	Hypothetical protein.	Hypothetical protein.	0.665
KKQ72539.1	KKQ72517.1	US93_C0008G0095	US93_C0008G0073	Hypothetical protein.	Hypothetical protein.	0.550
KKQ72539.1	KKQ73471.1	US93_C0008G0095	US93_C0001G0041	Hypothetical protein.	Hypothetical protein.	0.683

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.889

expected number of edges:

11

PPI enrichment p-value:

0.172

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

4 of 32

1.76

1.43

0.0010

GO:0006635

Fatty acid beta-oxidation

2 of 6

2.18

0.86

0.0251

GO:0006631

Fatty acid metabolic process

3 of 51

1.43

0.74

0.0263

GO:0019538

Protein metabolic process

6 of 335

0.91

0.63

0.0087

GO:0044238

Primary metabolic process

9 of 1504

0.44

0.28

0.0488

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070403

NAD+ binding

3 of 5

2.44

1.83

0.00038

GO:0004673

Protein histidine kinase activity

4 of 33

1.74

1.59

0.00038

GO:0003857

3-hydroxyacyl-CoA dehydrogenase activity

2 of 3

2.48

1.16

0.0076

GO:0004300

enoyl-CoA hydratase activity

2 of 5

2.26

1.05

0.0113

GO:0016836

Hydro-lyase activity

3 of 59

1.37

0.74

0.0239

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3785

PAS domain, and Diguanylate cyclase

4 of 10

2.26

2.49

1.39e-05

CL:1810

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, and Thiolase, C-terminal domain

4 of 11

2.22

2.47

1.39e-05

CL:3789

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and Putative diguanylate phosphodiesterase

3 of 5

2.44

2.13

9.86e-05

CL:1812

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, and Thiolase, C-terminal domain

2 of 5

2.26

1.13

0.0080

CL:194

Structural constituent of ribosome

2 of 6

2.18

1.07

0.0099

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

5 of 52

1.64

2.05

8.71e-06

map00362

Benzoate degradation

3 of 51

1.43

0.94

0.0077

map01200

Carbon metabolism

5 of 197

1.07

0.84

0.0024

map00071

Fatty acid degradation

2 of 20

1.66

0.76

0.0314

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

4 of 58

1.5

1.22

0.0015

KW-0276

Fatty acid metabolism

2 of 16

1.76

0.73

0.0384

KW-0418

Kinase

4 of 135

1.13

0.68

0.0182

KW-0520

NAD

3 of 73

1.27

0.63

0.0384

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00725

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

3 of 4

2.54

1.99

0.00020

PF02737

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

2 of 2

2.66

1.11

0.0098

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

4 of 27

1.83

1.99

4.93e-05

SM00387

Histidine kinase-like ATPases

4 of 30

1.79

1.95

4.93e-05

SM00091

PAS domain

3 of 15

1.96

1.82

0.00020

SM00448

cheY-homologous receiver domain

4 of 41

1.65

1.76

7.66e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 8

2.06

1.2

0.0051

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