KKT99935.1 protein (Moranbacteria bacterium GW2011GWC14518)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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Textmining

[Homology]

Score

KKT99935.1

Peptide chain release factor 1, peptide chain release factor RF-1. (355 aa)

Predicted Functional Partners:

KKU00648.1

0.999

KKU00712.1

0.999

KKU00737.1

0.999

rpsL

0.999

KKT99762.1

0.999

rpsJ

0.999

KKT99767.1

0.999

KKT99768.1

0.999

KKT99770.1

0.999

rplV

0.999

Your Current Organism:

Moranbacteria bacterium GW2011GWC14518

NCBI taxonomy Id: 1618696
Other names: C. Moranbacteria bacterium GW2011_GWC1_45_18, Candidatus Moranbacteria bacterium GW2011_GWC1_45_18, Parcubacteria (Moranbacteria) bacterium GW2011_GWC1_45_18

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKT99762.1	KKT99767.1	UX02_C0002G0081	UX02_C0002G0086	Ribosomal protein S7, small subunit ribosomal protein S7.	Ribosomal protein L3, large subunit ribosomal protein L3.	0.999
KKT99762.1	KKT99768.1	UX02_C0002G0081	UX02_C0002G0087	Ribosomal protein S7, small subunit ribosomal protein S7.	Ribosomal protein L4/L1e, large subunit ribosomal protein L4.	0.999
KKT99762.1	KKT99770.1	UX02_C0002G0081	UX02_C0002G0089	Ribosomal protein S7, small subunit ribosomal protein S7.	Ribosomal protein L2, large subunit ribosomal protein L2.	0.999
KKT99762.1	KKT99935.1	UX02_C0002G0081	UX02_C0002G0254	Ribosomal protein S7, small subunit ribosomal protein S7.	Peptide chain release factor 1, peptide chain release factor RF-1.	0.999
KKT99762.1	KKU00648.1	UX02_C0002G0081	UX02_C0001G0096	Ribosomal protein S7, small subunit ribosomal protein S7.	Hypothetical protein.	0.999
KKT99762.1	KKU00712.1	UX02_C0002G0081	UX02_C0001G0160	Ribosomal protein S7, small subunit ribosomal protein S7.	50S ribosomal protein L19.	0.999
KKT99762.1	KKU00737.1	UX02_C0002G0081	UX02_C0001G0185	Ribosomal protein S7, small subunit ribosomal protein S7.	30S ribosomal protein S15.	0.999
KKT99762.1	rplV	UX02_C0002G0081	UX02_C0002G0091	Ribosomal protein S7, small subunit ribosomal protein S7.	50S ribosomal protein L22, large subunit ribosomal protein L22.	0.999
KKT99762.1	rpsJ	UX02_C0002G0081	UX02_C0002G0085	Ribosomal protein S7, small subunit ribosomal protein S7.	30S ribosomal protein S10, small subunit ribosomal protein S10.	0.999
KKT99762.1	rpsL	UX02_C0002G0081	UX02_C0002G0080	Ribosomal protein S7, small subunit ribosomal protein S7.	30S ribosomal protein S12, small subunit ribosomal protein S12.	0.999
KKT99767.1	KKT99762.1	UX02_C0002G0086	UX02_C0002G0081	Ribosomal protein L3, large subunit ribosomal protein L3.	Ribosomal protein S7, small subunit ribosomal protein S7.	0.999
KKT99767.1	KKT99768.1	UX02_C0002G0086	UX02_C0002G0087	Ribosomal protein L3, large subunit ribosomal protein L3.	Ribosomal protein L4/L1e, large subunit ribosomal protein L4.	0.999
KKT99767.1	KKT99770.1	UX02_C0002G0086	UX02_C0002G0089	Ribosomal protein L3, large subunit ribosomal protein L3.	Ribosomal protein L2, large subunit ribosomal protein L2.	0.999
KKT99767.1	KKT99935.1	UX02_C0002G0086	UX02_C0002G0254	Ribosomal protein L3, large subunit ribosomal protein L3.	Peptide chain release factor 1, peptide chain release factor RF-1.	0.999
KKT99767.1	KKU00648.1	UX02_C0002G0086	UX02_C0001G0096	Ribosomal protein L3, large subunit ribosomal protein L3.	Hypothetical protein.	0.999
KKT99767.1	KKU00712.1	UX02_C0002G0086	UX02_C0001G0160	Ribosomal protein L3, large subunit ribosomal protein L3.	50S ribosomal protein L19.	0.999
KKT99767.1	KKU00737.1	UX02_C0002G0086	UX02_C0001G0185	Ribosomal protein L3, large subunit ribosomal protein L3.	30S ribosomal protein S15.	0.999
KKT99767.1	rplV	UX02_C0002G0086	UX02_C0002G0091	Ribosomal protein L3, large subunit ribosomal protein L3.	50S ribosomal protein L22, large subunit ribosomal protein L22.	0.999
KKT99767.1	rpsJ	UX02_C0002G0086	UX02_C0002G0085	Ribosomal protein L3, large subunit ribosomal protein L3.	30S ribosomal protein S10, small subunit ribosomal protein S10.	0.999
KKT99767.1	rpsL	UX02_C0002G0086	UX02_C0002G0080	Ribosomal protein L3, large subunit ribosomal protein L3.	30S ribosomal protein S12, small subunit ribosomal protein S12.	0.999

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

3.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901071

Glucosamine-containing compound metabolic process

4 of 58

1.88

1.54

0.00073

GO:0034221

Fungal-type cell wall chitin biosynthetic process

2 of 3

2.87

1.13

0.0092

GO:0006048

UDP-N-acetylglucosamine biosynthetic process

2 of 4

2.74

1.1

0.0103

GO:0006046

N-acetylglucosamine catabolic process

2 of 4

2.74

1.1

0.0103

GO:0006596

Polyamine biosynthetic process

2 of 5

2.64

1.09

0.0103

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047419

N-acetylgalactosamine-6-phosphate deacetylase activity

2 of 2

3.04

1.19

0.0073

GO:0008448

N-acetylglucosamine-6-phosphate deacetylase activity

2 of 2

3.04

1.19

0.0073

GO:0003824

Catalytic activity

11 of 5072

0.38

0.27

0.0382

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15182

Synthesis of UDP-N-acetyl-glucosamine, and Glucosamine catabolic process

5 of 8

2.84

4.94

5.87e-10

CL:18181

Melatonin metabolic process, and Staurosporine biosynthesis

3 of 5

2.82

2.66

1.34e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 153

1.56

1.82

2.37e-05

map01100

Metabolic pathways

11 of 3788

0.5

0.43

0.00022

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446210

Synthesis of UDP-N-acetyl-glucosamine

5 of 7

2.9

5.26

1.58e-10

MAP-446219

Synthesis of substrates in N-glycan biosythesis

5 of 22

2.4

4.09

7.99e-09

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

5 of 38

2.16

3.46

6.31e-08

MAP-446203

Asparagine N-linked glycosylation

5 of 161

1.53

1.71

4.62e-05

MAP-351202

Metabolism of polyamines

2 of 14

2.2

0.96

0.0168

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003764

N-acetylglucosamine-6-phosphate deacetylase

2 of 2

3.04

1.04

0.0136

IPR017932

Glutamine amidotransferase type 2 domain

2 of 6

2.56

0.83

0.0316

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