STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligALigase protein; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (677 aa)    
Predicted Functional Partners:
topA
Topoisomerase protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
   
 
 0.814
dnaX
Hypothetical protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
 0.809
KKT01212.1
Hypothetical protein.
       0.801
KKS99949.1
Hypothetical protein.
    
 0.781
KKT00121.1
Hypothetical protein.
    
 0.772
KKT01001.1
Hypothetical protein.
   
 
 0.769
KKT01208.1
Aspartate peptidase.
       0.742
KKT01209.1
Hypothetical protein.
       0.711
KKT01210.1
Hypothetical protein.
       0.711
KKT01211.1
Hypothetical protein.
       0.705
Your Current Organism:
Nomurabacteria bacterium GW2011GWA24315
NCBI taxonomy Id: 1618738
Other names: C. Nomurabacteria bacterium GW2011_GWA2_43_15, Candidatus Nomurabacteria bacterium GW2011_GWA2_43_15, Parcubacteria (Nomurabacteria) bacterium GW2011_GWA2_43_15
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.