KKS99110.1 protein (Nomurabacteria bacterium GW2011GWA24315)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KKS99110.1

Hypothetical protein. (271 aa)

Predicted Functional Partners:

KKS99109.1

0.976

KKS99111.1

0.759

leuS

0.660

KKS99107.1

0.645

KKS99425.1

0.638

KKT01282.1

0.466

KKT00001.1

0.466

KKT01168.1

0.457

KKT01169.1

0.457

KKS99370.1

0.448

Your Current Organism:

Nomurabacteria bacterium GW2011GWA24315

NCBI taxonomy Id: 1618738
Other names: C. Nomurabacteria bacterium GW2011_GWA2_43_15, Candidatus Nomurabacteria bacterium GW2011_GWA2_43_15, Parcubacteria (Nomurabacteria) bacterium GW2011_GWA2_43_15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKS99107.1	KKS99109.1	UV76_C0025G0002	UV76_C0025G0004	Hypothetical protein.	Hypothetical protein.	0.645
KKS99107.1	KKS99110.1	UV76_C0025G0002	UV76_C0025G0005	Hypothetical protein.	Hypothetical protein.	0.645
KKS99107.1	KKS99111.1	UV76_C0025G0002	UV76_C0025G0006	Hypothetical protein.	Integral membrane protein MviN.	0.624
KKS99107.1	leuS	UV76_C0025G0002	UV76_C0025G0003	Hypothetical protein.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.789
KKS99109.1	KKS99107.1	UV76_C0025G0004	UV76_C0025G0002	Hypothetical protein.	Hypothetical protein.	0.645
KKS99109.1	KKS99110.1	UV76_C0025G0004	UV76_C0025G0005	Hypothetical protein.	Hypothetical protein.	0.976
KKS99109.1	KKS99111.1	UV76_C0025G0004	UV76_C0025G0006	Hypothetical protein.	Integral membrane protein MviN.	0.759
KKS99109.1	KKS99370.1	UV76_C0025G0004	UV76_C0021G0012	Hypothetical protein.	Protein translocase subunit SecA.	0.448
KKS99109.1	KKS99425.1	UV76_C0025G0004	UV76_C0020G0004	Hypothetical protein.	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.638
KKS99109.1	KKT00001.1	UV76_C0025G0004	UV76_C0015G0017	Hypothetical protein.	Hypothetical protein.	0.466
KKS99109.1	KKT01168.1	UV76_C0025G0004	UV76_C0002G0081	Hypothetical protein.	Hypothetical protein.	0.457
KKS99109.1	KKT01169.1	UV76_C0025G0004	UV76_C0002G0082	Hypothetical protein.	Nucleoside diphosphate kinase; Belongs to the NDK family.	0.457
KKS99109.1	KKT01282.1	UV76_C0025G0004	UV76_C0001G0040	Hypothetical protein.	Protease Do.	0.466
KKS99109.1	leuS	UV76_C0025G0004	UV76_C0025G0003	Hypothetical protein.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.660
KKS99110.1	KKS99107.1	UV76_C0025G0005	UV76_C0025G0002	Hypothetical protein.	Hypothetical protein.	0.645
KKS99110.1	KKS99109.1	UV76_C0025G0005	UV76_C0025G0004	Hypothetical protein.	Hypothetical protein.	0.976
KKS99110.1	KKS99111.1	UV76_C0025G0005	UV76_C0025G0006	Hypothetical protein.	Integral membrane protein MviN.	0.759
KKS99110.1	KKS99370.1	UV76_C0025G0005	UV76_C0021G0012	Hypothetical protein.	Protein translocase subunit SecA.	0.448
KKS99110.1	KKS99425.1	UV76_C0025G0005	UV76_C0020G0004	Hypothetical protein.	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.638
KKS99110.1	KKT00001.1	UV76_C0025G0005	UV76_C0015G0017	Hypothetical protein.	Hypothetical protein.	0.466

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.351

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

4 of 24

1.92

1.77

0.00024

GO:0002098

tRNA wobble uridine modification

2 of 10

2.0

0.79

0.0328

GO:0044550

Secondary metabolite biosynthetic process

2 of 11

1.96

0.77

0.0352

GO:0032259

Methylation

4 of 143

1.15

0.65

0.0241

GO:0044283

Small molecule biosynthetic process

5 of 255

0.99

0.62

0.0163

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0102208

2-polyprenyl-6-hydroxyphenol methylase activity

2 of 2

2.7

0.96

0.0179

GO:0031177

Phosphopantetheine binding

2 of 2

2.7

0.96

0.0179

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

2 of 2

2.7

0.96

0.0179

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

2 of 4

2.4

0.95

0.0179

GO:0008757

S-adenosylmethionine-dependent methyltransferase activity

3 of 64

1.37

0.78

0.0182

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1403

0.51

0.34

0.0261

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6053

Mixed, incl. Ubiquinone metabolic process, and Biotin metabolic process

7 of 45

1.89

3.58

1.66e-09

CL:6055

Mixed, incl. Ubiquinone metabolic process, and ubiE/COQ5 methyltransferase family

5 of 27

1.97

2.95

3.17e-07

CL:6049

Mixed, incl. Photosynthesis, and Ubiquinone metabolic process

8 of 117

1.53

2.61

3.44e-09

CL:6056

Ubiquinone metabolic process, and ubiE/COQ5 methyltransferase family

4 of 22

1.96

2.28

1.65e-05

CL:6061

Ubiquinone biosynthesis, and FAD binding domain

3 of 10

2.18

1.91

0.00020

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

4 of 54

1.57

1.45

0.00043

map01053

Biosynthesis of siderophore group nonribosomal peptides

2 of 15

1.82

0.86

0.0216

map01110

Biosynthesis of secondary metabolites

6 of 563

0.73

0.46

0.0216

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0110142

Ubiquinone biosynthesis complex

4 of 10

2.3

2.83

2.94e-06

GOCC:0009366

Enterobactin synthetase complex

2 of 3

2.52

1.3

0.0041

GOCC:0032991

Protein-containing complex

8 of 774

0.71

0.54

0.0031

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

7 of 139

1.4

1.92

6.06e-07

KW-0831

Ubiquinone biosynthesis

2 of 7

2.15

1.02

0.0124

KW-0596

Phosphopantetheine

2 of 10

2.0

1.0

0.0124

KW-0949

S-adenosyl-L-methionine

3 of 52

1.46

0.87

0.0124

KW-0830

Ubiquinone

2 of 24

1.62

0.67

0.0481

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