KKQ55743.1 protein (Parcubacteria group bacterium GW2011GWA23813b)

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Known Interactions

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experimentally determined

Predicted Interactions

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[Homology]

Score

KKQ55743.1

UDP-N-acetylglucosamine 2-epimerase. (365 aa)

Predicted Functional Partners:

KKQ57888.1

0.992

KKQ57056.1

0.888

KKQ57885.1

0.885

KKQ55744.1

0.864

KKQ55746.1

0.864

KKQ57840.1

0.851

KKQ57199.1

0.830

KKQ55742.1

0.809

KKQ55745.1

0.794

KKQ56494.1

0.747

Your Current Organism:

Parcubacteria group bacterium GW2011GWA23813b

NCBI taxonomy Id: 1618780
Other names: P. group bacterium GW2011_GWA2_38_13b, Parcubacteria group bacterium GW2011_GWA2_38_13b

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ55742.1	KKQ55743.1	US76_C0024G0001	US76_C0024G0002	NAD-dependent epimerase/dehydratase.	UDP-N-acetylglucosamine 2-epimerase.	0.809
KKQ55742.1	KKQ55744.1	US76_C0024G0001	US76_C0024G0003	NAD-dependent epimerase/dehydratase.	Glycosyltransferase, group 1 family protein.	0.789
KKQ55742.1	KKQ55745.1	US76_C0024G0001	US76_C0024G0004	NAD-dependent epimerase/dehydratase.	Hypothetical protein.	0.787
KKQ55742.1	KKQ55746.1	US76_C0024G0001	US76_C0024G0005	NAD-dependent epimerase/dehydratase.	Glycosyl transferase group 1.	0.788
KKQ55742.1	KKQ56494.1	US76_C0024G0001	US76_C0015G0014	NAD-dependent epimerase/dehydratase.	Erythromycin biosynthesis sensory transduction protein eryC1.	0.631
KKQ55742.1	KKQ57056.1	US76_C0024G0001	US76_C0010G0006	NAD-dependent epimerase/dehydratase.	Hypothetical protein.	0.956
KKQ55742.1	KKQ57199.1	US76_C0024G0001	US76_C0008G0013	NAD-dependent epimerase/dehydratase.	PEP-CTERM system TPR-repeat lipoprotein.	0.465
KKQ55742.1	KKQ57840.1	US76_C0024G0001	US76_C0001G0011	NAD-dependent epimerase/dehydratase.	dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.959
KKQ55742.1	KKQ57885.1	US76_C0024G0001	US76_C0001G0056	NAD-dependent epimerase/dehydratase.	Nucleotidyl transferase family.	0.861
KKQ55743.1	KKQ55742.1	US76_C0024G0002	US76_C0024G0001	UDP-N-acetylglucosamine 2-epimerase.	NAD-dependent epimerase/dehydratase.	0.809
KKQ55743.1	KKQ55744.1	US76_C0024G0002	US76_C0024G0003	UDP-N-acetylglucosamine 2-epimerase.	Glycosyltransferase, group 1 family protein.	0.864
KKQ55743.1	KKQ55745.1	US76_C0024G0002	US76_C0024G0004	UDP-N-acetylglucosamine 2-epimerase.	Hypothetical protein.	0.794
KKQ55743.1	KKQ55746.1	US76_C0024G0002	US76_C0024G0005	UDP-N-acetylglucosamine 2-epimerase.	Glycosyl transferase group 1.	0.864
KKQ55743.1	KKQ56494.1	US76_C0024G0002	US76_C0015G0014	UDP-N-acetylglucosamine 2-epimerase.	Erythromycin biosynthesis sensory transduction protein eryC1.	0.747
KKQ55743.1	KKQ57056.1	US76_C0024G0002	US76_C0010G0006	UDP-N-acetylglucosamine 2-epimerase.	Hypothetical protein.	0.888
KKQ55743.1	KKQ57199.1	US76_C0024G0002	US76_C0008G0013	UDP-N-acetylglucosamine 2-epimerase.	PEP-CTERM system TPR-repeat lipoprotein.	0.830
KKQ55743.1	KKQ57840.1	US76_C0024G0002	US76_C0001G0011	UDP-N-acetylglucosamine 2-epimerase.	dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.851
KKQ55743.1	KKQ57885.1	US76_C0024G0002	US76_C0001G0056	UDP-N-acetylglucosamine 2-epimerase.	Nucleotidyl transferase family.	0.885
KKQ55743.1	KKQ57888.1	US76_C0024G0002	US76_C0001G0059	UDP-N-acetylglucosamine 2-epimerase.	UDP-glucose/GDP-mannose dehydrogenase family protein; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	0.992
KKQ55744.1	KKQ55742.1	US76_C0024G0003	US76_C0024G0001	Glycosyltransferase, group 1 family protein.	NAD-dependent epimerase/dehydratase.	0.789

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Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.878

expected number of edges:

18

PPI enrichment p-value:

1.55e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071555

Cell wall organization

5 of 19

1.27

0.95

0.0038

GO:0007049

Cell cycle

4 of 16

1.25

0.93

0.0038

GO:0009252

Peptidoglycan biosynthetic process

5 of 21

1.23

0.92

0.0038

GO:0051301

Cell division

4 of 17

1.22

0.91

0.0038

GO:0008360

Regulation of cell shape

5 of 22

1.21

0.9

0.0038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

6 of 25

1.23

1.19

0.00024

GO:0016881

Acid-amino acid ligase activity

4 of 10

1.45

1.11

0.0026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:656

Mur ligase, central, and Mur ligase family, catalytic domain

5 of 7

1.7

2.1

1.08e-05

CL:653

Peptidoglycan biosynthesis, and Cytokinesis

6 of 12

1.55

2.01

3.79e-06

CL:372

Ribonucleoside monophosphate metabolic process, and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

4 of 31

0.96

0.59

0.0190

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00471

D-Glutamine and D-glutamate metabolism

5 of 5

1.85

2.48

2.59e-06

map00550

Peptidoglycan biosynthesis

4 of 15

1.27

1.06

0.0014

map00220

Arginine biosynthesis

2 of 4

1.55

0.71

0.0369

map01100

Metabolic pathways

10 of 204

0.54

0.45

0.00045

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08245

Mur ligase middle domain

3 of 5

1.63

1.02

0.0075

PF02875

Mur ligase family, glutamate ligase domain

3 of 5

1.63

1.02

0.0075

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

1.63

0.77

0.0282

IPR036565

Mur-like, catalytic domain superfamily

3 of 5

1.63

0.77

0.0282

IPR013221

Mur ligase, central

3 of 5

1.63

0.77

0.0282

IPR004101

Mur ligase, C-terminal

3 of 5

1.63

0.77

0.0282

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