Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobBNAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily. (251 aa)    
Predicted Functional Partners:
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
    
 0.912
pncA
Nicotinamidase-like amidase; PFAM: Isochorismatase family.
   
 0.911
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
    
 0.910
ppnK
Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.908
AJI78327.1
Zn-finger containing NTP pyrophosphohydrolase; PFAM: NUDIX domain.
   
  0.907
AJI77681.1
PFAM: Protein of unknown function (DUF1648).
       0.826
AJI77679.1
PFAM: Antitoxin Phd_YefM, type II toxin-antitoxin system.
       0.682
lytR1
Transcriptional attenuator, LytR family; PFAM: Cell envelope-related transcriptional attenuator domain; TIGRFAM: cell envelope-related function transcriptional attenuator common domain.
   
    0.594
kdpE
PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
   
    0.578
lysG
Transcriptional regulator, ArgP family; PFAM: LysR substrate binding domain; Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: transcriptional regulator, ArgP family.
   
    0.539
Your Current Organism:
Corynebacterium singulare
NCBI taxonomy Id: 161899
Other names: C. singulare, CCUG 37330, CIP 105491, DSM 44357, IBS B52218, IFO 16162, JCM 10385, NBRC 16162
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