STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tlyAPFAM: FtsJ-like methyltransferase; S4 domain; TIGRFAM: TlyA family rRNA methyltransferase/putative hemolysin. (269 aa)    
Predicted Functional Partners:
ppnK
Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
  
 0.970
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.785
AJI78996.1
PFAM: Tetratricopeptide repeat.
  
  
 0.785
AJI78995.1
Putative sugar phosphatase of HAD superfamily; PFAM: HAD-hyrolase-like; Haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase Superfamily Class (subfamily) IIA.
     
 0.782
recN
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
 
  
 0.777
pncA
Nicotinamidase-like amidase; PFAM: Isochorismatase family.
     
 0.761
rsmG
16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
   
 0.751
AJI78994.1
Hypothetical protein.
       0.746
AJI78988.1
NTP pyrophosphohydrolase; PFAM: NUDIX domain.
  
    0.704
AJI78989.1
PFAM: Protein of unknown function (DUF3186).
       0.701
Your Current Organism:
Corynebacterium singulare
NCBI taxonomy Id: 161899
Other names: C. singulare, CCUG 37330, CIP 105491, DSM 44357, IBS B52218, IFO 16162, JCM 10385, NBRC 16162
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.