Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aptPRPP-binding protein, adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (184 aa)    
Predicted Functional Partners:
purB
PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.971
AJI79068.1
5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase; PFAM: 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family.
    
 0.960
purH
PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
  
 0.955
adk
Adenylate kinase-like kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 0.926
iunH1
PFAM: Inosine-uridine preferring nucleoside hydrolase.
     
 0.923
amn
AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
   
 0.919
AJI79330.1
YfiH family protein; PFAM: Multi-copper polyphenol oxidoreductase laccase; TIGRFAM: YfiH family protein; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.904
nagD
Putative sugar phosphatase of HAD superfamily; PFAM: HAD-hyrolase-like; Haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily subfamily IIA hydrolase, TIGR01457; Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Belongs to the HAD-like hydrolase superfamily.
     
  0.900
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.886
secD
Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
  
    0.850
Your Current Organism:
Corynebacterium singulare
NCBI taxonomy Id: 161899
Other names: C. singulare, CCUG 37330, CIP 105491, DSM 44357, IBS B52218, IFO 16162, JCM 10385, NBRC 16162
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