| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cobB | pncA | CSING_00560 | CSING_09270 | NAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily. | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | 0.911 |
| glsA | pncA | CSING_09265 | CSING_09270 | L-glutaminase; PFAM: Glutaminase; STAS domain; TIGRFAM: glutaminase A; Belongs to the glutaminase family. | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | 0.691 |
| gyrA | gyrB | CSING_00040 | CSING_00025 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.998 |
| gyrA | pncA | CSING_00040 | CSING_09270 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | 0.658 |
| gyrA | rpoB | CSING_00040 | CSING_02160 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.833 |
| gyrA | rpsA | CSING_00040 | CSING_07520 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Ribosomal protein S1; PFAM: S1 RNA binding domain; TIGRFAM: ribosomal protein S1. | 0.534 |
| gyrA | rpsL | CSING_00040 | CSING_02195 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. | 0.670 |
| gyrA | tlyA | CSING_00040 | CSING_07315 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | PFAM: FtsJ-like methyltransferase; S4 domain; TIGRFAM: TlyA family rRNA methyltransferase/putative hemolysin. | 0.630 |
| gyrB | gyrA | CSING_00025 | CSING_00040 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.998 |
| gyrB | irp2C | CSING_00025 | CSING_01210 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Nonribosomal peptide synthase; Condensation domain; AMP-binding enzyme C-terminal domain; TIGRFAM: amino acid adenylation domain. | 0.499 |
| gyrB | pncA | CSING_00025 | CSING_09270 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | 0.654 |
| gyrB | rpoB | CSING_00025 | CSING_02160 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.805 |
| gyrB | rpsL | CSING_00025 | CSING_02195 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. | 0.437 |
| gyrB | tlyA | CSING_00025 | CSING_07315 | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | PFAM: FtsJ-like methyltransferase; S4 domain; TIGRFAM: TlyA family rRNA methyltransferase/putative hemolysin. | 0.611 |
| irp2C | gyrB | CSING_01210 | CSING_00025 | Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Nonribosomal peptide synthase; Condensation domain; AMP-binding enzyme C-terminal domain; TIGRFAM: amino acid adenylation domain. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.499 |
| irp2C | pncA | CSING_01210 | CSING_09270 | Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Nonribosomal peptide synthase; Condensation domain; AMP-binding enzyme C-terminal domain; TIGRFAM: amino acid adenylation domain. | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | 0.637 |
| irp2C | rpoB | CSING_01210 | CSING_02160 | Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Nonribosomal peptide synthase; Condensation domain; AMP-binding enzyme C-terminal domain; TIGRFAM: amino acid adenylation domain. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.527 |
| irp2C | rpsL | CSING_01210 | CSING_02195 | Amino acid adenylation enzyme/thioester reductase family protein; PFAM: Thioesterase domain; Phosphopantetheine attachment site; Methyltransferase domain; AMP-binding enzyme; Nonribosomal peptide synthase; Condensation domain; AMP-binding enzyme C-terminal domain; TIGRFAM: amino acid adenylation domain. | SSU ribosomal protein S12P; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. | 0.496 |
| pncA | cobB | CSING_09270 | CSING_00560 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | NAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily. | 0.911 |
| pncA | glsA | CSING_09270 | CSING_09265 | Nicotinamidase-like amidase; PFAM: Isochorismatase family. | L-glutaminase; PFAM: Glutaminase; STAS domain; TIGRFAM: glutaminase A; Belongs to the glutaminase family. | 0.691 |
