Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nrdE1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (731 aa)    
Predicted Functional Partners:
nrdF1
PFAM: Ribonucleotide reductase, small chain; TIGRFAM: ribonucleoside-diphosphate reductase, class 1b, beta subunit.
 
 0.999
nrdF2
Ribonucleoside-diphosphate reductase class Ib beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
 
 0.997
nrdI1
Ribonucleoside-diphosphate reductase 2, operon protein nrdI; Probably involved in ribonucleotide reductase function.
 
  
 0.963
AJI79690.1
Ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit; PFAM: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein NrdH.
 
 0.922
tmk
PFAM: Thymidylate kinase; TIGRFAM: dTMP kinase.
  
 
 0.920
cmk
PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
  
 
 0.912
adk
Adenylate kinase-like kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
 0.908
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.907
nrdI2
Ribonucleoside-diphosphate reductase 2, operon protein nrdI; Probably involved in ribonucleotide reductase function.
 
  
 0.904
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.901
Your Current Organism:
Corynebacterium singulare
NCBI taxonomy Id: 161899
Other names: C. singulare, CCUG 37330, CIP 105491, DSM 44357, IBS B52218, IFO 16162, JCM 10385, NBRC 16162
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