KKQ40182.1 protein (Magasanikbacteria bacterium GW2011GWA2378)

Nodes:

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

KKQ40182.1

Beta-lactamase-like protein. (264 aa)

Predicted Functional Partners:

KKQ41110.1

0.819

KKQ41226.1

0.810

KKQ40254.1

0.757

KKQ39727.1

0.750

KKQ39728.1

0.741

KKQ40175.1

0.735

rpmC

0.726

rsmH

0.722

KKQ39036.1

0.722

KKQ41138.1

0.719

Your Current Organism:

Magasanikbacteria bacterium GW2011GWA2378

NCBI taxonomy Id: 1619036
Other names: C. Magasanikbacteria bacterium GW2011_GWA2_37_8, Candidatus Magasanikbacteria bacterium GW2011_GWA2_37_8, Parcubacteria (Magasanikbacteria) bacterium GW2011_GWA2_37_8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ39036.1	KKQ40182.1	US58_C0043G0009	US58_C0023G0016	Ribosomal RNA small subunit methyltransferase H.	Beta-lactamase-like protein.	0.722
KKQ39036.1	KKQ40254.1	US58_C0043G0009	US58_C0022G0003	Ribosomal RNA small subunit methyltransferase H.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase.	0.454
KKQ39036.1	rpmC	US58_C0043G0009	US58_C0036G0011	Ribosomal RNA small subunit methyltransferase H.	30S ribosomal protein S17; Belongs to the universal ribosomal protein uL29 family.	0.646
KKQ39727.1	KKQ39728.1	US58_C0029G0005	US58_C0029G0006	Cysteine desulfurase.	Nitrogen-fixing NifU domain protein.	0.999
KKQ39727.1	KKQ40182.1	US58_C0029G0005	US58_C0023G0016	Cysteine desulfurase.	Beta-lactamase-like protein.	0.750
KKQ39728.1	KKQ39727.1	US58_C0029G0006	US58_C0029G0005	Nitrogen-fixing NifU domain protein.	Cysteine desulfurase.	0.999
KKQ39728.1	KKQ40182.1	US58_C0029G0006	US58_C0023G0016	Nitrogen-fixing NifU domain protein.	Beta-lactamase-like protein.	0.741
KKQ40175.1	KKQ40182.1	US58_C0023G0009	US58_C0023G0016	Transcriptional regulator, XRE family.	Beta-lactamase-like protein.	0.735
KKQ40175.1	KKQ40254.1	US58_C0023G0009	US58_C0022G0003	Transcriptional regulator, XRE family.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase.	0.676
KKQ40182.1	KKQ39036.1	US58_C0023G0016	US58_C0043G0009	Beta-lactamase-like protein.	Ribosomal RNA small subunit methyltransferase H.	0.722
KKQ40182.1	KKQ39727.1	US58_C0023G0016	US58_C0029G0005	Beta-lactamase-like protein.	Cysteine desulfurase.	0.750
KKQ40182.1	KKQ39728.1	US58_C0023G0016	US58_C0029G0006	Beta-lactamase-like protein.	Nitrogen-fixing NifU domain protein.	0.741
KKQ40182.1	KKQ40175.1	US58_C0023G0016	US58_C0023G0009	Beta-lactamase-like protein.	Transcriptional regulator, XRE family.	0.735
KKQ40182.1	KKQ40254.1	US58_C0023G0016	US58_C0022G0003	Beta-lactamase-like protein.	UDP-N-acetylglucosamine 1-carboxyvinyltransferase.	0.757
KKQ40182.1	KKQ41110.1	US58_C0023G0016	US58_C0005G0035	Beta-lactamase-like protein.	ThiJ/PfpI domain-containing protein.	0.819
KKQ40182.1	KKQ41138.1	US58_C0023G0016	US58_C0005G0063	Beta-lactamase-like protein.	Beta-lactamase domain protein.	0.719
KKQ40182.1	KKQ41226.1	US58_C0023G0016	US58_C0003G0009	Beta-lactamase-like protein.	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein.	0.810
KKQ40182.1	rpmC	US58_C0023G0016	US58_C0036G0011	Beta-lactamase-like protein.	30S ribosomal protein S17; Belongs to the universal ribosomal protein uL29 family.	0.726
KKQ40182.1	rsmH	US58_C0023G0016	US58_C0022G0029	Beta-lactamase-like protein.	S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.	0.722
KKQ40254.1	KKQ39036.1	US58_C0022G0003	US58_C0043G0009	UDP-N-acetylglucosamine 1-carboxyvinyltransferase.	Ribosomal RNA small subunit methyltransferase H.	0.454

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.929

expected number of edges:

15

PPI enrichment p-value:

3.88e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033014

Tetrapyrrole biosynthetic process

11 of 21

2.07

6.86

2.33e-19

GO:0009236

Cobalamin biosynthetic process

10 of 16

2.15

6.83

7.88e-18

GO:0032259

Methylation

6 of 59

1.36

1.69

4.61e-06

GO:0006541

Glutamine metabolic process

2 of 11

1.61

0.67

0.0474

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008168

Methyltransferase activity

6 of 57

1.38

1.51

4.80e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35864536

(2022) Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants.

8 of 10

2.26

6.17

1.52e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3483

Cobalamin metabolic process

10 of 10

2.35

8.09

4.45e-19

CL:3480

Tetrapyrrole biosynthetic process, and ABC transporter, permease protein, BtuC-like

11 of 31

1.9

5.72

2.08e-18

CL:3485

Tetrapyrrole methylase

5 of 5

2.35

3.97

1.14e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

11 of 44

1.75

4.72

2.22e-17

map01100

Metabolic pathways

11 of 814

0.48

0.41

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0169

Cobalamin biosynthesis

4 of 6

2.18

2.56

8.09e-06

KW-0489

Methyltransferase

5 of 48

1.37

1.4

0.00014

KW-0949

S-adenosyl-L-methionine

3 of 34

1.3

0.68

0.0290

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00590

Tetrapyrrole (Corrin/Porphyrin) Methylases

5 of 6

2.27

3.47

1.09e-07

PF07685

CobB/CobQ-like glutamine amidotransferase domain

2 of 3

2.18

0.78

0.0363

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035996

Tetrapyrrole methylase superfamily

5 of 6

2.27

3.28

2.81e-07

IPR014777

Tetrapyrrole methylase, subdomain 1

5 of 6

2.27

3.28

2.81e-07

IPR014776

Tetrapyrrole methylase, subdomain 2

5 of 6

2.27

3.28

2.81e-07

IPR000878

Tetrapyrrole methylase

5 of 6

2.27

3.28

2.81e-07

IPR011698

CobB/CobQ-like glutamine amidotransferase

2 of 2

2.35

0.9

0.0225

(more ...)

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