KKQ72178.1 protein (Peregrinibacteria bacterium GW2011GWA23836)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KKQ72178.1

RNA polymerase sigma factor. (295 aa)

Predicted Functional Partners:

KKQ72179.1

0.789

KKQ72177.1

0.661

KKQ72176.1

0.640

KKQ71971.1

0.551

KKQ71326.1

0.537

KKQ71970.1

0.534

KKQ71937.1

0.522

KKQ72180.1

0.521

KKQ72252.1

0.500

KKQ72181.1

0.485

Your Current Organism:

Peregrinibacteria bacterium GW2011GWA23836

NCBI taxonomy Id: 1619055
Other names: C. Peregrinibacteria bacterium GW2011_GWA2_38_36, Candidatus Peregrinibacteria bacterium GW2011_GWA2_38_36

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KKQ71326.1	KKQ71937.1	US92_C0006G0050	US92_C0002G0027	Topoisomerase protein.	DNA-directed RNA polymerase subunit alpha.	0.777
KKQ71326.1	KKQ71970.1	US92_C0006G0050	US92_C0002G0060	Topoisomerase protein.	DNA-directed RNA polymerase subunit beta'.	0.754
KKQ71326.1	KKQ71971.1	US92_C0006G0050	US92_C0002G0061	Topoisomerase protein.	DNA-directed RNA polymerase subunit beta.	0.459
KKQ71326.1	KKQ72176.1	US92_C0006G0050	US92_C0001G0097	Topoisomerase protein.	RNA polymerase sigma factor.	0.537
KKQ71326.1	KKQ72177.1	US92_C0006G0050	US92_C0001G0098	Topoisomerase protein.	RNA polymerase sigma factor.	0.537
KKQ71326.1	KKQ72178.1	US92_C0006G0050	US92_C0001G0099	Topoisomerase protein.	RNA polymerase sigma factor.	0.537
KKQ71326.1	KKQ72179.1	US92_C0006G0050	US92_C0001G0100	Topoisomerase protein.	RNA polymerase sigma factor.	0.537
KKQ71326.1	KKQ72252.1	US92_C0006G0050	US92_C0001G0173	Topoisomerase protein.	Bifunctional GMP synthase/glutamine amidotransferase protein.	0.611
KKQ71937.1	KKQ71326.1	US92_C0002G0027	US92_C0006G0050	DNA-directed RNA polymerase subunit alpha.	Topoisomerase protein.	0.777
KKQ71937.1	KKQ71970.1	US92_C0002G0027	US92_C0002G0060	DNA-directed RNA polymerase subunit alpha.	DNA-directed RNA polymerase subunit beta'.	0.999
KKQ71937.1	KKQ71971.1	US92_C0002G0027	US92_C0002G0061	DNA-directed RNA polymerase subunit alpha.	DNA-directed RNA polymerase subunit beta.	0.999
KKQ71937.1	KKQ72176.1	US92_C0002G0027	US92_C0001G0097	DNA-directed RNA polymerase subunit alpha.	RNA polymerase sigma factor.	0.522
KKQ71937.1	KKQ72177.1	US92_C0002G0027	US92_C0001G0098	DNA-directed RNA polymerase subunit alpha.	RNA polymerase sigma factor.	0.522
KKQ71937.1	KKQ72178.1	US92_C0002G0027	US92_C0001G0099	DNA-directed RNA polymerase subunit alpha.	RNA polymerase sigma factor.	0.522
KKQ71937.1	KKQ72179.1	US92_C0002G0027	US92_C0001G0100	DNA-directed RNA polymerase subunit alpha.	RNA polymerase sigma factor.	0.522
KKQ71937.1	KKQ72252.1	US92_C0002G0027	US92_C0001G0173	DNA-directed RNA polymerase subunit alpha.	Bifunctional GMP synthase/glutamine amidotransferase protein.	0.811
KKQ71970.1	KKQ71326.1	US92_C0002G0060	US92_C0006G0050	DNA-directed RNA polymerase subunit beta'.	Topoisomerase protein.	0.754
KKQ71970.1	KKQ71937.1	US92_C0002G0060	US92_C0002G0027	DNA-directed RNA polymerase subunit beta'.	DNA-directed RNA polymerase subunit alpha.	0.999
KKQ71970.1	KKQ71971.1	US92_C0002G0060	US92_C0002G0061	DNA-directed RNA polymerase subunit beta'.	DNA-directed RNA polymerase subunit beta.	0.999
KKQ71970.1	KKQ72176.1	US92_C0002G0060	US92_C0001G0097	DNA-directed RNA polymerase subunit beta'.	RNA polymerase sigma factor.	0.534

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

25

PPI enrichment p-value:

7.3e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 92

1.32

2.29

4.91e-12

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019843

rRNA binding

10 of 37

1.68

3.81

1.21e-13

GO:0003735

Structural constituent of ribosome

10 of 49

1.56

3.21

7.30e-13

GO:0000049

tRNA binding

5 of 19

1.67

2.13

6.14e-06

GO:0003676

Nucleic acid binding

11 of 225

0.93

1.11

6.14e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044391

Ribosomal subunit

6 of 12

1.94

3.67

2.03e-09

GO:0005840

Ribosome

10 of 53

1.52

3.08

7.12e-13

GO:0015935

Small ribosomal subunit

3 of 6

1.94

1.87

0.00015

GO:0015934

Large ribosomal subunit

3 of 6

1.94

1.87

0.00015

GO:0005622

Intracellular anatomical structure

11 of 682

0.45

0.39

0.00015

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:64

Ribosome, and Translational elongation

11 of 72

1.43

2.78

1.87e-13

CL:68

Ribosome, and Elongation factor

9 of 61

1.41

2.45

1.49e-10

CL:72

Ribosome

5 of 28

1.5

1.8

1.36e-05

CL:154

rRNA binding, and Elongation factor Tu GTP binding domain

4 of 18

1.59

1.68

9.76e-05

CL:75

Ribosome

4 of 22

1.51

1.5

0.00019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 52

1.53

3.13

5.28e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044391

Ribosomal subunit

6 of 15

1.85

3.0

6.83e-08

GOCC:0015934

Large ribosomal subunit

4 of 6

2.07

2.65

3.45e-06

GOCC:0005840

Ribosome

7 of 36

1.53

2.37

6.83e-08

GOCC:0022626

Cytosolic ribosome

4 of 10

1.85

2.23

1.26e-05

GOCC:0043229

Intracellular organelle

10 of 171

1.01

1.22

6.83e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 52

1.53

3.1

8.99e-13

KW-0687

Ribonucleoprotein

10 of 52

1.53

3.1

8.99e-13

KW-0820

tRNA-binding

4 of 10

1.85

2.17

1.77e-05

KW-0699

rRNA-binding

6 of 31

1.53

2.15

7.32e-07

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