STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCP95630.1methylated-DNA-[protein]-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (192 aa)    
Predicted Functional Partners:
SCP95198.1
Exodeoxyribonuclease-3.
  
 0.951
SCP95075.1
3-methyladenine DNA glycosylase AlkD.
      0.822
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.579
SCP99089.1
hypoxanthine-DNA glycosylase.
 
    
 0.565
SCP94787.1
Predicted DNA-binding protein, MmcQ/YjbR family.
  
 
 0.511
SCP99879.1
DNA polymerase-4.
 
 
 0.447
dinB
DNA polymerase-4; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.435
sfsA
Sugar fermentation stimulation protein/A/G-specific adenine glycosylase,TIGR01084; Belongs to the SfsA family.
  
  
 0.431
SCP95632.1
PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein.
  
    0.428
nfo
Deoxyribonuclease-4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
   
 
 0.428
Your Current Organism:
Anaerobium acetethylicum
NCBI taxonomy Id: 1619234
Other names: A. acetethylicum, Anaerobium acetethylicum Patil et al. 2015, Clostridiales bacterium GluBS11, DSM 29698, KCTC 15450, LMG 28619, LMG:28619, strain GluBS11
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