Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (501 aa)    
Predicted Functional Partners:
purH
Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.991
fhs
Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.984
folD
Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase).
  
 0.983
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.977
sdaAB
Putative L-serine dehydratase, beta chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.960
sdaAA
Putative L-serine dehydratase, alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.960
CEM62058.1
Phosphoribosylformylglycinamidine synthase.
  
  
 0.951
folA
Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.
  
 
 0.940
ilvA
Threonine ammonia-lyase.
    
 0.935
ltaA
L-allo-threonine aldolase.
   
 0.933
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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