node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEM60454.1 | rho | TPHV1_10122 | TPHV1_70088 | R3H domain protein. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.712 |
CEM60454.1 | yidC | TPHV1_10122 | TPHV1_10123 | R3H domain protein. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.965 |
CEM61668.1 | SecE | TPHV1_20205 | TPHV1_30006 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Protein translocase subunit SecE (modular protein). | 0.932 |
CEM61668.1 | ftsY | TPHV1_20205 | TPHV1_20152 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Signal recognition particle-docking protein FtsY. | 0.931 |
CEM61668.1 | secA | TPHV1_20205 | TPHV1_50048 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Protein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. | 0.981 |
CEM61668.1 | secG | TPHV1_20205 | TPHV1_110025 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.934 |
CEM61668.1 | secY | TPHV1_20205 | TPHV1_80015 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.931 |
CEM61668.1 | yajC | TPHV1_20205 | TPHV1_40040 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.954 |
CEM61668.1 | yidC | TPHV1_20205 | TPHV1_10123 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.931 |
SecE | CEM61668.1 | TPHV1_30006 | TPHV1_20205 | Protein translocase subunit SecE (modular protein). | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.932 |
SecE | ftsY | TPHV1_30006 | TPHV1_20152 | Protein translocase subunit SecE (modular protein). | Signal recognition particle-docking protein FtsY. | 0.967 |
SecE | rho | TPHV1_30006 | TPHV1_70088 | Protein translocase subunit SecE (modular protein). | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.490 |
SecE | secA | TPHV1_30006 | TPHV1_50048 | Protein translocase subunit SecE (modular protein). | Protein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. | 0.985 |
SecE | secD | TPHV1_30006 | TPHV1_40039 | Protein translocase subunit SecE (modular protein). | Protein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.840 |
SecE | secG | TPHV1_30006 | TPHV1_110025 | Protein translocase subunit SecE (modular protein). | Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.997 |
SecE | secY | TPHV1_30006 | TPHV1_80015 | Protein translocase subunit SecE (modular protein). | Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.994 |
SecE | yajC | TPHV1_30006 | TPHV1_40040 | Protein translocase subunit SecE (modular protein). | Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.956 |
SecE | yidC | TPHV1_30006 | TPHV1_10123 | Protein translocase subunit SecE (modular protein). | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.969 |
ftsY | CEM61668.1 | TPHV1_20152 | TPHV1_20205 | Signal recognition particle-docking protein FtsY. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.931 |
ftsY | SecE | TPHV1_20152 | TPHV1_30006 | Signal recognition particle-docking protein FtsY. | Protein translocase subunit SecE (modular protein). | 0.967 |