node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEM61310.1 | mutL-2 | TPHV1_170041 | TPHV1_30193 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (modular protein). | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.448 |
CEM61310.1 | polA | TPHV1_170041 | TPHV1_80113 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (modular protein). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.662 |
CEM61310.1 | uvrB | TPHV1_170041 | TPHV1_50053 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (modular protein). | Excinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] | 0.628 |
CEM61310.1 | uvrC | TPHV1_170041 | TPHV1_20122 | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (modular protein). | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.603 |
CEM62051.1 | uvrC | TPHV1_270008 | TPHV1_20122 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.664 |
CEM62761.1 | mutL-2 | TPHV1_50021 | TPHV1_30193 | UvrD/REP helicase. | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.515 |
CEM62761.1 | polA | TPHV1_50021 | TPHV1_80113 | UvrD/REP helicase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.628 |
CEM62761.1 | radA | TPHV1_50021 | TPHV1_180043 | UvrD/REP helicase. | DNA repair protein RadA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.635 |
CEM62761.1 | uvrA | TPHV1_50021 | TPHV1_210050 | UvrD/REP helicase. | ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.553 |
CEM62761.1 | uvrB | TPHV1_50021 | TPHV1_50053 | UvrD/REP helicase. | Excinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] | 0.795 |
CEM62761.1 | uvrC | TPHV1_50021 | TPHV1_20122 | UvrD/REP helicase. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.742 |
dnaQ | polA | TPHV1_40180 | TPHV1_80113 | DNA polymerase III subunit epsilon. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.569 |
dnaQ | uvrC | TPHV1_40180 | TPHV1_20122 | DNA polymerase III subunit epsilon. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.921 |
mutL-2 | CEM61310.1 | TPHV1_30193 | TPHV1_170041 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein (modular protein). | 0.448 |
mutL-2 | CEM62761.1 | TPHV1_30193 | TPHV1_50021 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | UvrD/REP helicase. | 0.515 |
mutL-2 | pcrA | TPHV1_30193 | TPHV1_380002 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase PcrA. | 0.515 |
mutL-2 | polA | TPHV1_30193 | TPHV1_80113 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.931 |
mutL-2 | uvrA | TPHV1_30193 | TPHV1_210050 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.470 |
mutL-2 | uvrB | TPHV1_30193 | TPHV1_50053 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Excinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] | 0.472 |
mutL-2 | uvrC | TPHV1_30193 | TPHV1_20122 | DNA mismatch repair protein MutL (fragment); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.623 |