node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEM62058.1 | folD | TPHV1_270015 | TPHV1_290005 | Phosphoribosylformylglycinamidine synthase. | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | 0.893 |
CEM62058.1 | glyA | TPHV1_270015 | TPHV1_10035 | Phosphoribosylformylglycinamidine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
CEM62058.1 | purC | TPHV1_270015 | TPHV1_270014 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.999 |
CEM62058.1 | purD | TPHV1_270015 | TPHV1_30041 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. | 0.999 |
CEM62058.1 | purE | TPHV1_270015 | TPHV1_270016 | Phosphoribosylformylglycinamidine synthase. | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.998 |
CEM62058.1 | purF | TPHV1_270015 | TPHV1_270017 | Phosphoribosylformylglycinamidine synthase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
CEM62058.1 | purH | TPHV1_270015 | TPHV1_30042 | Phosphoribosylformylglycinamidine synthase. | Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
CEM62058.1 | purM | TPHV1_270015 | TPHV1_180004 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |
CEM62058.1 | purN | TPHV1_270015 | TPHV1_180005 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
CEM62145.1 | purD | TPHV1_30040 | TPHV1_30041 | Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function. | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. | 0.773 |
CEM62145.1 | purH | TPHV1_30040 | TPHV1_30042 | Conserved membrane hypothetical protein; Homologs of previously reported genes of unknown function. | Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.668 |
folD | CEM62058.1 | TPHV1_290005 | TPHV1_270015 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Phosphoribosylformylglycinamidine synthase. | 0.893 |
folD | glyA | TPHV1_290005 | TPHV1_10035 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.986 |
folD | purC | TPHV1_290005 | TPHV1_270014 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.499 |
folD | purD | TPHV1_290005 | TPHV1_30041 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. | 0.918 |
folD | purE | TPHV1_290005 | TPHV1_270016 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.657 |
folD | purF | TPHV1_290005 | TPHV1_270017 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.710 |
folD | purH | TPHV1_290005 | TPHV1_30042 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.981 |
folD | purM | TPHV1_290005 | TPHV1_180004 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.754 |
folD | purN | TPHV1_290005 | TPHV1_180005 | Bifunctional protein FolD (Includes: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.978 |