Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hlyHemolysin. (395 aa)    
Predicted Functional Partners:
CEM63147.1
Cys/Met metabolism PLP-dependent enzyme (modular protein).
   
 0.931
pepD
Xaa-His dipeptidase.
    
 0.815
ilvA
Threonine ammonia-lyase.
    
  0.813
CEM63143.1
Homoserine dehydrogenase.
    
 0.807
coaBC
Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
    
  0.803
CEM61346.1
Transcriptional regulator, LuxR family.
    
   0.660
CEM62440.1
Hypothetical protein; No homology to any previously reported sequences.
    
   0.660
CEM62441.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
    
   0.660
mdeA
Methionine gamma-lyase.
 
  
 0.648
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
Server load: low (14%) [HD]