STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdDAnaerobic ribonucleoside-triphosphate reductase. (702 aa)    
Predicted Functional Partners:
CEM61902.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
     0.936
CEM61901.1
Putative anaerobic ribonucleoside-triphosphate reductase activating protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
 0.929
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.916
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.904
CEM63218.1
Tetratricopeptide repeat protein.
    
 0.902
CEM60750.1
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.900
CEM61520.1
Putative adenylyl cyclase CyaB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
     
  0.900
CEM61588.1
Adenylate/guanylate cyclase catalytic domain protein.
     
  0.900
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
  0.900
nrdR
Transcriptional repressor NrdR.
     
 0.817
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.