CEM62534.1 protein (Treponema phagedenis) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

CEM62534.1

Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (123 aa)

Predicted Functional Partners:

CEM62533.1

0.698

CEM63003.1

0.674

argS

0.627

CEM61816.1

0.618

CEM62056.1

0.614

CEM62159.1

0.608

upp

0.558

CEM63095.1

0.514

CEM62532.1

0.512

CEM61762.1

0.495

Your Current Organism:

Treponema phagedenis

NCBI taxonomy Id: 162
Other names: T. phagedenis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEM61762.1	CEM61816.1	TPHV1_200052	TPHV1_210049	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	0.775
CEM61762.1	CEM62056.1	TPHV1_200052	TPHV1_270013	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Phosphoribosyl transferase domain protein.	0.754
CEM61762.1	CEM62159.1	TPHV1_200052	TPHV1_30054	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.725
CEM61762.1	CEM62533.1	TPHV1_200052	TPHV1_40036	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I.	0.648
CEM61762.1	CEM62534.1	TPHV1_200052	TPHV1_40037	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.495
CEM61762.1	CEM63003.1	TPHV1_200052	TPHV1_510070	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.760
CEM61762.1	CEM63095.1	TPHV1_200052	TPHV1_60083	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Pentapeptide repeat family protein.	0.663
CEM61762.1	upp	TPHV1_200052	TPHV1_180049	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Putative uracil phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.648
CEM61816.1	CEM61762.1	TPHV1_210049	TPHV1_200052	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.775
CEM61816.1	CEM62056.1	TPHV1_210049	TPHV1_270013	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Phosphoribosyl transferase domain protein.	0.769
CEM61816.1	CEM62159.1	TPHV1_210049	TPHV1_30054	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.717
CEM61816.1	CEM62533.1	TPHV1_210049	TPHV1_40036	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I.	0.793
CEM61816.1	CEM62534.1	TPHV1_210049	TPHV1_40037	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.618
CEM61816.1	CEM63003.1	TPHV1_210049	TPHV1_510070	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.773
CEM61816.1	CEM63095.1	TPHV1_210049	TPHV1_60083	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Pentapeptide repeat family protein.	0.593
CEM61816.1	upp	TPHV1_210049	TPHV1_180049	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	Putative uracil phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.766
CEM62056.1	CEM61762.1	TPHV1_270013	TPHV1_200052	Phosphoribosyl transferase domain protein.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.754
CEM62056.1	CEM61816.1	TPHV1_270013	TPHV1_210049	Phosphoribosyl transferase domain protein.	Conserved exported hypothetical protein; Homologs of previously reported genes of unknown function.	0.769
CEM62056.1	CEM62159.1	TPHV1_270013	TPHV1_30054	Phosphoribosyl transferase domain protein.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.639
CEM62056.1	CEM62533.1	TPHV1_270013	TPHV1_40036	Phosphoribosyl transferase domain protein.	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I.	0.749

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.865

expected number of edges:

10

PPI enrichment p-value:

0.0194

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

5 of 58

1.28

0.93

0.0046

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008233

Peptidase activity

5 of 69

1.2

0.86

0.0056

GO:0008238

Exopeptidase activity

3 of 19

1.54

0.81

0.0207

GO:0008237

Metallopeptidase activity

3 of 22

1.48

0.78

0.0230

GO:0140096

Catalytic activity, acting on a protein

6 of 133

1.0

0.72

0.0056

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33467737

(2021) Adjunct Culture of Non-Starter Lactic Acid Bacteria for the Production of Provola Dei Nebrodi PDO Cheese: In Vitro Screening and Pilot-Scale Cheese-Making.

4 of 4

2.34

2.09

0.00011

PMID:31555049

(2019) Aerococcus urinae and Globicatella sanguinis Persist in Polymicrobial Urethral Catheter Biofilms Examined in Longitudinal Profiles at the Proteomic Level.

3 of 7

1.97

0.81

0.0296

PMID:32733419

(2020) A Systems-Wide Analysis of Proteolytic and Lipolytic Pathways Uncovers The Flavor-Forming Potential of The Gram-Positive Bacterium Macrococcus caseolyticus subsp. caseolyticus.

3 of 8

1.92

0.8

0.0296

PMID:28384209

(2017) Analyses of the probiotic property and stress resistance-related genes of Lactococcus lactis subsp. lactis NCDO 2118 through comparative genomics and in vitro assays.

3 of 9

1.86

0.8

0.0296

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2169

Mixed, incl. Aminopeptidase, and Oligopeptidase F

5 of 7

2.2

3.21

2.90e-07

CL:4143

Threonine/Serine exporter, ThrE

3 of 5

2.12

1.63

0.00072

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0031

Aminopeptidase

3 of 8

1.92

1.34

0.0022

KW-0645

Protease

4 of 43

1.31

0.98

0.0036

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