Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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aptPutative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (234 aa)    
Predicted Functional Partners:
purH
Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
 0.972
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 0.957
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.924
nadN
Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the 5'-nucleotidase family.
    
 0.919
deoD
Purine nucleoside phosphorylase DeoD-type.
    
 0.917
CEM63203.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
    
  0.908
CEM62058.1
Phosphoribosylformylglycinamidine synthase.
  
  
 0.862
yjgF
Ketoacid-binding protein; Function of homologous gene experimentally demonstrated in an other organism; putative enzyme.
 
  
 0.770
mnmG
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
      0.720
CEM61701.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
   
  
 0.708
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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