| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CEM62058.1 | tgt | TPHV1_270015 | TPHV1_50099 | Phosphoribosylformylglycinamidine synthase. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.567 |
| CEM62838.1 | CEM62840.1 | TPHV1_50098 | TPHV1_50100 | PBS lyase HEAT-like repeat protein. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.639 |
| CEM62838.1 | rlmJ | TPHV1_50098 | TPHV1_50097 | PBS lyase HEAT-like repeat protein. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. | 0.773 |
| CEM62838.1 | tgt | TPHV1_50098 | TPHV1_50099 | PBS lyase HEAT-like repeat protein. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.817 |
| CEM62838.1 | truB | TPHV1_50098 | TPHV1_50107 | PBS lyase HEAT-like repeat protein. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.424 |
| CEM62840.1 | CEM62838.1 | TPHV1_50100 | TPHV1_50098 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | PBS lyase HEAT-like repeat protein. | 0.639 |
| CEM62840.1 | rlmJ | TPHV1_50100 | TPHV1_50097 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. | 0.639 |
| CEM62840.1 | tgt | TPHV1_50100 | TPHV1_50099 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.639 |
| mreC | nusA | TPHV1_150052 | TPHV1_50103 | Cell shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | 0.418 |
| mreC | tgt | TPHV1_150052 | TPHV1_50099 | Cell shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.691 |
| nusA | mreC | TPHV1_50103 | TPHV1_150052 | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | Cell shape-determining protein MreC; Involved in formation and maintenance of cell shape. | 0.418 |
| nusA | tgt | TPHV1_50103 | TPHV1_50099 | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.558 |
| nusA | tig | TPHV1_50103 | TPHV1_120045 | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.887 |
| nusA | trmD | TPHV1_50103 | TPHV1_50010 | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | tRNA (guanine-1-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. | 0.949 |
| nusA | truB | TPHV1_50103 | TPHV1_50107 | Transcription termination/antitermination protein NusA; Participates in both transcription termination and antitermination. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.941 |
| queA | tgt | TPHV1_100019 | TPHV1_50099 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.996 |
| queA | truB | TPHV1_100019 | TPHV1_50107 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.532 |
| rlmJ | CEM62838.1 | TPHV1_50097 | TPHV1_50098 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. | PBS lyase HEAT-like repeat protein. | 0.773 |
| rlmJ | CEM62840.1 | TPHV1_50097 | TPHV1_50100 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.639 |
| rlmJ | tgt | TPHV1_50097 | TPHV1_50099 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] | 0.777 |
