Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metAAspartokinase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (599 aa)    
Predicted Functional Partners:
CEM63143.1
Homoserine dehydrogenase.
 0.998
CEM63147.1
Cys/Met metabolism PLP-dependent enzyme (modular protein).
 
 
 0.995
asd
Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
  
 0.963
mdeA
Methionine gamma-lyase.
 
  
 0.938
ilvA
Threonine ammonia-lyase.
  
 0.920
CEM62930.1
Putative threonine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
 
 0.915
CEM61578.1
Putative threonine synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
 
 
 0.906
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.875
sdaAB
Putative L-serine dehydratase, beta chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the iron-sulfur dependent L-serine dehydratase family.
    
 0.844
sdaAA
Putative L-serine dehydratase, alpha chain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the iron-sulfur dependent L-serine dehydratase family.
    
 0.844
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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