Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nnrEYjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (496 aa)    
Predicted Functional Partners:
CEM61264.1
Hydrolase, NUDIX family.
  
 0.948
CEM60834.1
DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
  
 0.842
CEM61224.1
ATP-dependent RNA helicase RhlB (modular protein); Belongs to the DEAD box helicase family.
  
 0.842
CEM62159.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
 0.842
CEM63181.1
DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
  
 0.842
groL
Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
   0.822
glgP
Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
   0.748
tsaE
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE.
  
 
 0.739
nifJ
Pyruvate-flavodoxin oxidoreductase.
  
   0.737
glgX
Glycogen operon protein GlgX homolog; Belongs to the glycosyl hydrolase 13 family.
  
    0.701
Your Current Organism:
Treponema phagedenis
NCBI taxonomy Id: 162
Other names: T. phagedenis
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