KRN78090.1 protein (Weissella minor) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

KRN78090.1

Hypothetical protein. (80 aa)

Predicted Functional Partners:

KRN77342.1

0.593

KRN78087.1

0.484

KRN78091.1

0.472

thyA

0.442

KRN78089.1

0.442

KRN77387.1

0.436

Your Current Organism:

Weissella minor

NCBI taxonomy Id: 1620
Other names: ATCC 35412, BCRC 14049, CCRC 14049, CCRC:14049, CCUG 30668, CECT 572, CIP 102978, DSM 20014, LMG 9847, LMG:9847, Lactobacillus minor, Lactobacillus viridescens subsp. minor, NCIMB 701973, W. minor, strain 3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRN77342.1	KRN78090.1	IV67_GL001699	IV67_GL000106	Purine operon repressor.	Hypothetical protein.	0.593
KRN77387.1	KRN78090.1	IV67_GL001745	IV67_GL000106	Signal protein.	Hypothetical protein.	0.436
KRN78087.1	KRN78089.1	IV67_GL000103	IV67_GL000105	LytR family transcriptional regulator.	Hypothetical protein.	0.675
KRN78087.1	KRN78090.1	IV67_GL000103	IV67_GL000106	LytR family transcriptional regulator.	Hypothetical protein.	0.484
KRN78087.1	thyA	IV67_GL000103	IV67_GL000104	LytR family transcriptional regulator.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.675
KRN78089.1	KRN78087.1	IV67_GL000105	IV67_GL000103	Hypothetical protein.	LytR family transcriptional regulator.	0.675
KRN78089.1	KRN78090.1	IV67_GL000105	IV67_GL000106	Hypothetical protein.	Hypothetical protein.	0.442
KRN78089.1	thyA	IV67_GL000105	IV67_GL000104	Hypothetical protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.991
KRN78090.1	KRN77342.1	IV67_GL000106	IV67_GL001699	Hypothetical protein.	Purine operon repressor.	0.593
KRN78090.1	KRN77387.1	IV67_GL000106	IV67_GL001745	Hypothetical protein.	Signal protein.	0.436
KRN78090.1	KRN78087.1	IV67_GL000106	IV67_GL000103	Hypothetical protein.	LytR family transcriptional regulator.	0.484
KRN78090.1	KRN78089.1	IV67_GL000106	IV67_GL000105	Hypothetical protein.	Hypothetical protein.	0.442
KRN78090.1	KRN78091.1	IV67_GL000106	IV67_GL000107	Hypothetical protein.	Branched-chain amino acid aminotransferase.	0.472
KRN78090.1	thyA	IV67_GL000106	IV67_GL000104	Hypothetical protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.442
KRN78091.1	KRN78090.1	IV67_GL000107	IV67_GL000106	Branched-chain amino acid aminotransferase.	Hypothetical protein.	0.472
KRN78091.1	thyA	IV67_GL000107	IV67_GL000104	Branched-chain amino acid aminotransferase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.489
thyA	KRN78087.1	IV67_GL000104	IV67_GL000103	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	LytR family transcriptional regulator.	0.675
thyA	KRN78089.1	IV67_GL000104	IV67_GL000105	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Hypothetical protein.	0.991
thyA	KRN78090.1	IV67_GL000104	IV67_GL000106	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Hypothetical protein.	0.442
thyA	KRN78091.1	IV67_GL000104	IV67_GL000107	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Branched-chain amino acid aminotransferase.	0.489

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

11 of 143

1.98

6.22

8.84e-19

GO:0006352

DNA-templated transcription, initiation

5 of 48

2.11

3.43

5.27e-08

GO:0006383

Transcription by RNA polymerase III

4 of 22

2.35

3.22

5.15e-07

GO:0070897

Transcription preinitiation complex assembly

3 of 21

2.25

2.09

9.69e-05

GO:0070898

RNA polymerase III preinitiation complex assembly

2 of 2

3.09

1.87

0.00041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

4 of 19

2.42

2.89

2.93e-06

GO:0001016

RNA polymerase III transcription regulatory region sequence-specific DNA binding

3 of 5

2.87

2.88

5.29e-06

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 24

2.31

2.84

2.93e-06

GO:0140296

General transcription initiation factor binding

3 of 11

2.53

2.42

2.94e-05

GO:0001006

RNA polymerase III type 3 promoter sequence-specific DNA binding

2 of 4

2.79

1.61

0.0012

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090576

RNA polymerase III transcription regulator complex

4 of 8

2.79

4.04

2.91e-08

GO:0005666

RNA polymerase III complex

4 of 16

2.49

3.52

1.71e-07

GO:0000126

Transcription factor TFIIIB complex

3 of 3

3.09

3.36

7.54e-07

GO:0000428

DNA-directed RNA polymerase complex

6 of 82

1.96

3.35

2.11e-08

GO:0005667

Transcription regulator complex

5 of 75

1.92

2.87

3.54e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3703

RNA Polymerase III Transcription Initiation From Type 1 Promoter, and RNA polymerase I complex

9 of 36

2.49

8.33

1.90e-18

CL:3711

RNA polymerase III complex, and RNA polymerase III preinitiation complex assembly

7 of 12

2.86

8.11

2.80e-16

CL:3709

RNA polymerase III complex, and RNA Polymerase I Transcription Initiation

8 of 26

2.58

8.0

4.42e-17

CL:3442

Mixed, incl. Nuclear DNA-directed RNA polymerase complex, and Tyrosinase activity

11 of 169

1.91

5.75

1.90e-18

CL:3713

RNA polymerase III complex

3 of 7

2.73

2.67

1.17e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

5 of 39

2.2

3.72

1.89e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76046

RNA Polymerase III Transcription Initiation

11 of 29

2.67

12.1

2.81e-26

MAP-74158

RNA Polymerase III Transcription

11 of 29

2.67

12.1

2.81e-26

MAP-76066

RNA Polymerase III Transcription Initiation From Type 2 Promoter

10 of 26

2.68

11.02

1.40e-23

MAP-76061

RNA Polymerase III Transcription Initiation From Type 1 Promoter

10 of 26

2.68

11.02

1.40e-23

MAP-74160

Gene expression (Transcription)

11 of 572

1.38

2.59

1.46e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 76

1.91

2.53

2.84e-06

GOCC:0005666

RNA polymerase III complex

2 of 5

2.7

1.48

0.0020

GOCC:0032991

Protein-containing complex

10 of 2302

0.73

0.67

4.35e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 13

2.46

2.29

5.06e-05

KW-0548

Nucleotidyltransferase

2 of 27

1.96

0.91

0.0184

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000812

Transcription factor TFIIB

2 of 3

2.92

1.0

0.0158

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

2 of 14

2.25

0.9

0.0219

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