STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRN76068.1ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (838 aa)    
Predicted Functional Partners:
dnaK
Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.943
KRN76067.1
Hypothetical protein.
  
  
 0.909
clpP
Atp-dependent clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.855
KRN76723.1
Chaperone CbpA protein.
  
 
 0.838
KRN77592.1
Hypothetical protein; Belongs to the peptidase S14 family.
  
 
 0.832
KRN77491.1
Peptidase S14, ClpP; Belongs to the peptidase S14 family.
  
 
 0.832
KRN76318.1
Adaptor protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.
    
 
 0.812
KRN77454.1
Hypothetical protein; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.782
grpE
Chaperone GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...]
  
 
 0.777
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 
 0.634
Your Current Organism:
Weissella minor
NCBI taxonomy Id: 1620
Other names: ATCC 35412, BCRC 14049, CCRC 14049, CCRC:14049, CCUG 30668, CECT 572, CIP 102978, DSM 20014, LMG 9847, LMG:9847, Lactobacillus minor, Lactobacillus viridescens subsp. minor, NCIMB 701973, W. minor, strain 3
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