STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoApurinic endonuclease APN1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (282 aa)    
Predicted Functional Partners:
AKM85002.1
Polymerase I protein.
  
 
 0.802
AKM84708.1
ATP dependent DNA ligase, DNA ligase (ATP).
  
  
 0.746
AKM84739.1
Polymerase III subunit epsilon, DNA polymerase III subunit epsilon protein.
  
  
 0.683
topA
Topoisomerase I, DNA topoisomerase I protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken stran [...]
   
 
 0.636
AKM84706.1
Bifunctional phosphoglucose/phosphomannose isomerase, glucose/mannose-6-phosphate isomerase.
       0.636
AKM84617.1
Superoxide dismutase.
  
  
 0.507
AKM85000.1
formamidopyrimidine-DNA glycosylase, formamidopyrimidine-DNA glycosylase; Belongs to the FPG family.
     
 0.453
engA
GTP-binding protein EngA, GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
    0.430
ruvA
Holliday junction DNA helicase RuvA, holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
   
  
 0.423
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.423
Your Current Organism:
candidate division Kazan bacterium GW2011GWA15015
NCBI taxonomy Id: 1620412
Other names: bacterium GW2011_GWA1_50_15, c. division Kazan bacterium GW2011_GWA1_50_15, candidate division Kazan bacterium GW2011_GWA1_50_15
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