STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuSleucyl-tRNA synthetase, leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (784 aa)    
Predicted Functional Partners:
topA
Topoisomerase I, DNA topoisomerase I protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken stran [...]
   
 
 0.999
gltX
glutamyl-tRNA synthetase, glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.972
metG
methionyl-tRNA synthetase, methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
0.970
pheT
phenylalanyl-tRNA synthetase subunit beta, phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.964
ileS
isoleucyl-tRNA synthetase, isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
0.950
lysS
lysyl-tRNA synthetase, lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.924
AKM84832.1
arginyl-tRNA synthetase, arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.924
proS
prolyl-tRNA synthetase, prolyl-tRNA synthetase.
  
 0.906
AKM85002.1
Polymerase I protein.
  
  
 0.889
ligA
NAD-dependent DNA ligase, DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
   
 
 0.813
Your Current Organism:
candidate division Kazan bacterium GW2011GWA15015
NCBI taxonomy Id: 1620412
Other names: bacterium GW2011_GWA1_50_15, c. division Kazan bacterium GW2011_GWA1_50_15, candidate division Kazan bacterium GW2011_GWA1_50_15
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