pilQ protein (Desulfofervidus auxilii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

pilQ

Type IV pilus secretin PilQ. (736 aa)

Predicted Functional Partners:

pilP

0.995

pilM

0.986

pilN-2

0.986

pilO

0.985

AMM39866.1

0.982

pilN

0.822

AMM39871.1

0.806

pilC

0.801

AMM40411.1

0.773

pilA

0.739

Your Current Organism:

Desulfofervidus auxilii

NCBI taxonomy Id: 1621989
Other names: C. Desulfofervidus auxilii, Candidatus Desulfofervidus auxilii, delta proteobacterium HotSeep1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMM39866.1	AMM39871.1	HS1_000059	HS1_000064	Peptidoglycan-binding protein LysM.	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	0.633
AMM39866.1	pilA	HS1_000059	HS1_000117	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein.	0.667
AMM39866.1	pilC	HS1_000059	HS1_002257	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilC.	0.557
AMM39866.1	pilM	HS1_000059	HS1_000600	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilM.	0.900
AMM39866.1	pilN	HS1_000059	HS1_000070	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilN.	0.418
AMM39866.1	pilN-2	HS1_000059	HS1_000601	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilN.	0.765
AMM39866.1	pilO	HS1_000059	HS1_000602	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilO.	0.910
AMM39866.1	pilP	HS1_000059	HS1_000603	Peptidoglycan-binding protein LysM.	Type IV pilus assembly protein PilP.	0.723
AMM39866.1	pilQ	HS1_000059	HS1_000604	Peptidoglycan-binding protein LysM.	Type IV pilus secretin PilQ.	0.982
AMM39871.1	AMM39866.1	HS1_000064	HS1_000059	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Peptidoglycan-binding protein LysM.	0.633
AMM39871.1	pilC	HS1_000064	HS1_002257	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilC.	0.964
AMM39871.1	pilM	HS1_000064	HS1_000600	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilM.	0.790
AMM39871.1	pilN	HS1_000064	HS1_000070	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilN.	0.901
AMM39871.1	pilN-2	HS1_000064	HS1_000601	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilN.	0.680
AMM39871.1	pilO	HS1_000064	HS1_000602	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilO.	0.686
AMM39871.1	pilP	HS1_000064	HS1_000603	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus assembly protein PilP.	0.474
AMM39871.1	pilQ	HS1_000064	HS1_000604	Type II secretory protein GspE; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.	Type IV pilus secretin PilQ.	0.806
AMM40411.1	pilM	HS1_000605	HS1_000600	Phosphoribosylglycinamide formyltransferase.	Type IV pilus assembly protein PilM.	0.773
AMM40411.1	pilN-2	HS1_000605	HS1_000601	Phosphoribosylglycinamide formyltransferase.	Type IV pilus assembly protein PilN.	0.773
AMM40411.1	pilO	HS1_000605	HS1_000602	Phosphoribosylglycinamide formyltransferase.	Type IV pilus assembly protein PilO.	0.773

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

7 of 587

0.74

0.41

0.0498

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25423265

(2015) Hydroxycinnamic Acid Degradation, a Broadly Conserved Trait, Protects Ralstonia solanacearum from Chemical Plant Defenses and Contributes to Root Colonization and Virulence.

8 of 11

2.53

7.22

1.62e-15

PMID:31392803

(2019) Involvement of a PadR regulator PrhP on virulence of Ralstonia solanacearum by controlling detoxification of phenolic acids and type III secretion system.

3 of 18

1.89

1.09

0.0074

PMID:32283875

(2020) Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health.

2 of 2

2.67

1.04

0.0129

PMID:23298573

(2013) Characterization and genomic analysis of kraft lignin biodegradation by the beta-proteobacterium Cupriavidus basilensis B-8.

2 of 5

2.27

0.8

0.0339

PMID:17959646

(2007) A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus.

2 of 5

2.27

0.8

0.0339

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2543

Mixed, incl. Degradation of aromatic compounds, and Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site

8 of 28

2.12

5.27

4.94e-13

CL:2555

Mixed, incl. Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site, and enoyl-CoA hydratase activity

5 of 5

2.67

4.54

2.33e-09

CL:2205

Mixed, incl. Fatty acid metabolic process, and Valine, leucine and isoleucine degradation

9 of 197

1.33

2.04

4.65e-09

CL:2573

Benzoate degradation

3 of 13

2.03

1.58

0.00080

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rso01220

Degradation of aromatic compounds

3 of 33

1.63

1.06

0.0060

rso00362

Benzoate degradation

3 of 39

1.55

1.03

0.0060

rso00627

Aminobenzoate degradation

2 of 16

1.76

0.88

0.0187

rso01120

Microbial metabolism in diverse environments

5 of 272

0.93

0.67

0.0062

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