STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (185 aa)    
Predicted Functional Partners:
pyrD
Diguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate.
  
 0.978
AMM41101.1
Orotidine 5'-phosphate decarboxylase, subfamily 1, core domain protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
  
 
 0.978
AMM40124.1
Oxidoreductase FAD/NAD(P)-binding domain-containing protein.
  
 
 0.976
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
 
 0.966
pyrB
Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.953
carB
Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.
  
 
 0.951
pyrR
Phosphoribosyl transferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
  
 
 0.944
carA
Carbamoyl phosphate synthase small subunit; Belongs to the CarA family.
  
  
 0.939
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.852
purD
Phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family.
  
  
 0.706
Your Current Organism:
Desulfofervidus auxilii
NCBI taxonomy Id: 1621989
Other names: C. Desulfofervidus auxilii, Candidatus Desulfofervidus auxilii, delta proteobacterium HotSeep1
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