STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AN4351.2Programmed cell death 6-interacting protein; pH-response regulator protein palA/RIM20; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB via vps32 to its substrate pacC (By similarity) (847 aa)    
Predicted Functional Partners:
AN4240.2
Charged multivesicular body protein 4; Vacuolar-sorting protein snf7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB)
   
 0.997
AN0256.2
Calpain-like protease palB; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC, yielding the 53 kDa 'open' conformation intermediate protein, which is committed to further processing. Required for virulence in invasive pulmonary aspergillosis (IPA)
    
 0.980
AN2855.2
pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. Required for virulence in invasive pulmonary aspergillosis (IPA)
    
 
 0.971
AN6886.2
pH-response regulator protein palH/RIM21; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Might be a pH sensor
    
 
 0.951
AN1844.2
pH-response regulator protein palF/RIM8; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH
    
 
 0.937
AN2071.2
Hepatocyte growth factor-regulated tyrosine kinase substrate; Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane
   
 0.915
AN2521.2
Endosomal sorting complex protein TSG101, putative (AFU_orthologue; AFUA_3G14380)
   
 0.900
AN2066.2
Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB)
   
 0.876
ANIA_01365
SNF7 family protein (AFU_orthologue; AFUA_1G09220); Belongs to the SNF7 family
   
 0.856
palI
Hypothetical protein; Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Might be a pH sensor
    
 
 0.837
Your Current Organism:
Aspergillus nidulans
NCBI taxonomy Id: 162425
Other names: A. nidulans, ATCC 10074, Aspergillus nidulellus, Emericella nidulans
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